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Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves

Zhang, Shuping ; Santos, Renato L. ; Tsolis, Renée M. ; Mirold, Susanne ; Hardt, Wolf-Dietrich ; Adams, L. Garry ; Bäumler, Andreas J.

In: FEMS Microbiology Letters, 2002, vol. 217, no. 2, p. 243-247

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    Title
    • Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves
    Author
    • Zhang, Shuping. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA
    • Santos, Renato L.. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA
    • Tsolis, Renée M.. Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843-1114, USA
    • Mirold, Susanne. Max von Pettenkofer Institut, Pettenkoferstr. 9a, 80336 Munich, Germany
    • Hardt, Wolf-Dietrich. Max von Pettenkofer Institut, Pettenkoferstr. 9a, 80336 Munich, Germany
    • Adams, L. Garry. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA
    • Bäumler, Andreas J.. Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843-1114, USA
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:301711
    Summary
    Epidemiological evidence shows that the sopE1 gene is associated with Salmonella Typhimurium phage types causing epidemics in cattle. In this study we demonstrate that horizontal transfer of the sopE1 gene by lysogenic conversion with the SopEΦ increased enteropathogenicity of S. Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones