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Regression of AIDS-Related Kaposi's Sarcoma During Therapy with Thalidomide

Solèr, Rolf A. ; Howard, Mark ; Brink, Nicola S. ; Gibb, Diana ; Tedder, Richard S. ; Nadal, David

In: Clinical Infectious Diseases, 1996, vol. 23, no. 3, p. 501-503

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    Title
    • Regression of AIDS-Related Kaposi's Sarcoma During Therapy with Thalidomide
    Author
    • Solèr, Rolf A.. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    • Howard, Mark. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    • Brink, Nicola S.. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    • Gibb, Diana. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    • Tedder, Richard S.. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    • Nadal, David. Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland, London, London, England
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 1996, vol. 23, no. 3, p. 501-503. University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:301631
    Summary
    A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of granulocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood