HLA-Bw4 Homozygosity Is Associated with an Impaired CD4 T Cell Recovery after Initiation of Antiretroviral Therapy

Rauch, Andri ; Nolan, David ; Furrer, Hansjakob ; McKinnon, Elizabeth ; John, Mina ; Mallal, Simon ; Gaudieri, Silvana ; Günthard, Huldrych F. ; Schmid, Patrick ; Battegay, Manuel ; Hirschel, Bernard ; Telenti, Amalio ; James, Ian

In: Clinical Infectious Diseases, 2008, vol. 46, no. 12, p. 1921-1925

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    Summary
    We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/µL for HLA-Bw4 homozygotes, 321 cells/µL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/µL for HLA-Bw6 homozygotes (P=.01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy