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A Retrospective Survey of HIV Drug Resistance Among Patients 1 Year After Initiation of Antiretroviral Therapy at 4 Clinics in Malawi

Wadonda-Kabondo, Nellie ; Hedt, Bethany L. ; van Oosterhout, Joep J. ; Moyo, Kundai ; Limbambala, Eddie ; Bello, George ; Chilima, Ben ; Schouten, Erik ; Harries, Anthony ; Massaquoi, Moses ; Porter, Carol ; Weigel, Ralf ; Hosseinipour, Mina ; Aberle-Grasse, John ; Jordan, Michael R. ; Kabuluzi, Storn ; Bennett, Diane E.

In: Clinical Infectious Diseases, 2012, vol. 54, p. S355-S361

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    Titre
    • A Retrospective Survey of HIV Drug Resistance Among Patients 1 Year After Initiation of Antiretroviral Therapy at 4 Clinics in Malawi
    Auteur
    • Wadonda-Kabondo, Nellie. Ministry of Health, Lilongwe, Malawi
    • Hedt, Bethany L.. Community Health Sciences Unit, Harvard Medical School, Boston, Massachusetts
    • van Oosterhout, Joep J.. University of Malawi, College of Medicine, Queen Elizabeth Central Hospital, Blantyre
    • Moyo, Kundai. Ministry of Health, Lilongwe, Malawi
    • Limbambala, Eddie. World Health Organization, Lilongwe, Malawi
    • Bello, George. Ministry of Health, Lilongwe, Malawi
    • Chilima, Ben. Ministry of Health, Lilongwe, Malawi
    • Schouten, Erik. Ministry of Health, Lilongwe, Malawi
    • Harries, Anthony. International Union Against Tuberculosis and Lung Disease, Paris, France
    • Massaquoi, Moses. Médecins Sans Frontières, Belgium
    • Porter, Carol. Howard University Technical Support Project
    • Weigel, Ralf. Lighthouse Trust, Lilongwe, Malawi
    • Hosseinipour, Mina. University of North Carolina Project, Lilongwe, Malawi
    • Aberle-Grasse, John. Centers for Disease Control and Prevention, Atlanta, Georgia
    • Jordan, Michael R.. World Health Organization, Geneva, Switzerland
    • Kabuluzi, Storn. Ministry of Health, Lilongwe, Malawi
    • Bennett, Diane E.. Centers for Disease Control and Prevention, Atlanta, Georgia
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Clinical Infectious Diseases, 2012, vol. 54, p. S355-S361. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300916
    Summary
    In 2004, Malawi began scaling up its national antiretroviral therapy (ART) program. Because of limited treatment options, population-level surveillance of acquired human immunodeficiency virus drug resistance (HIVDR) is critical to ensuring long-term treatment success. The World Health Organization target for clinic-level HIVDR prevention at 12 months after ART initiation is ≥70%. In 2007, viral load and HIVDR genotyping was performed in a retrospective cohort of 596 patients at 4 ART clinics. Overall, HIVDR prevention (using viral load ≤400 copies/mL) was 72% (95% confidence interval [CI], 67%-77%; range by site, 60%-83%) and detected HIVDR was 3.4% (95% CI, 1.8%-5.8%; range by site, 2.5%-4.7%). Results demonstrate virological suppression and HIVDR consistent with previous reports from sub-Saharan Africa. High rates of attrition because of loss to follow-up were noted and merit attention