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Sodium chloride vs. sodium bicarbonate for the prevention of contrast medium-induced nephropathy: a randomized controlled trial

Klima, Theresia ; Christ, Andreas ; Marana, Ivana ; Kalbermatter, Stefan ; Uthoff, Heiko ; Burri, Emanuel ; Hartwiger, Sabine ; Schindler, Christian ; Breidthardt, Tobias ; Marenzi, Giancarlo ; Mueller, Christian

In: European Heart Journal, 2012, vol. 33, no. 16, p. 2071-2079

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    Titre
    • Sodium chloride vs. sodium bicarbonate for the prevention of contrast medium-induced nephropathy: a randomized controlled trial
    Auteur
    • Klima, Theresia. Department of Nephrology, University Hospital Basel, Basel, Switzerland
    • Christ, Andreas. Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    • Marana, Ivana. Centro Cardiologico Monzino, Milan University, Milan, Italy
    • Kalbermatter, Stefan. Department of Nephrology, Kantonsspital Liestal, Liestal, Switzerland
    • Uthoff, Heiko. Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    • Burri, Emanuel. Department of Gastroenterology, University Hospital Basel, Basel, Switzerland
    • Hartwiger, Sabine. Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    • Schindler, Christian. Swiss Tropical and Public Health Institute, University Hospital Basel, Basel, Switzerland
    • Breidthardt, Tobias. Department of Nephrology, University Hospital Basel, Basel, Switzerland
    • Marenzi, Giancarlo. Centro Cardiologico Monzino, Milan University, Milan, Italy
    • Mueller, Christian. Department of Cardiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Heart Journal, 2012, vol. 33, no. 16, p. 2071-2079. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300839
    Summary
    Aims The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN. Methods and results We performed a prospective, randomized trial between March 2005 and December 2009, including 258 consecutive patients with renal insufficiency undergoing intravascular contrast procedures. Patients were randomized to receive intravenous volume supplementation with either (A) sodium chloride 0.9% 1 mL/kg/h for at least 12h prior and after the procedure or (B) sodium bicarbonate (166 mEq/L) 3 mL/kg for 1h before and 1 mL/kg/h for 6h after the procedure or (C) sodium bicarbonate (166 mEq/L) 3 mL/kg over 20min before the procedure plus sodium bicarbonate orally (500 mg per 10 kg). The primary endpoint was the change in estimated glomerular filtration rate (eGFR) within 48h after contrast. Secondary endpoints included the development of CIN. The maximum change in eGFR was significantly greater in Group B compared with Group A {mean difference −3.9 [95% confidence interval (CI), −6.8 to −1] mL/min/1.73 m2, P = 0.009} and similar between Groups C and B [mean difference 1.3 (95% CI, −1.7-4.3) mL/min/1.73 m2, P = 0.39]. The incidence of CIN was significantly lower in Group A (1%) vs. Group B (9%, P = 0.02) and similar between Groups B and C (10%, P = 0.9). Conclusion Volume supplementation with 24 h sodium chloride 0.9% is superior to sodium bicarbonate for the prevention of CIN. A short-term regimen with sodium bicarbonate is non-inferior to a 7 h regimen. ClinicalTrials.gov Identifier: NCT00130598