Fulltext

Dietary magnesium intake can affect mechanical properties of rat carotid artery

Laurant, Pascal ; Hayoz, Daniel ; Brunner, Hans ; Berthelot, Alain

In: British Journal of Nutrition, 2000, vol. 84, no. 5, p. 757-764

Add to personal list
    Title
    • Dietary magnesium intake can affect mechanical properties of rat carotid artery
    Author
    • Laurant, Pascal. Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
    • Hayoz, Daniel. Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
    • Brunner, Hans. Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
    • Berthelot, Alain. Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
    Document Type
    • Postprint
    Language
    • English
    Published in
    • British Journal of Nutrition, 2000, vol. 84, no. 5, p. 757-764. Cambridge University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:300614
    Summary
    The purpose of the present study was to determine the effects of Mg deficiency and supplementation on the mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously using an echo-tracking device. Systolic, diastolic and mean intra-arterial pressures were not significantly different in Mg-deficient, -supplemented or control rats. Histological examination showed a larger cross-sectional area, increased intima-media thickness and a greater media:lumen value in carotid artery of Mg-deficient rats, indicating that Mg deficiency may directly stimulate growth and/or proliferation of arterial wall components. In addition, we observed a negative linear relationship between intima-media thickness and plasma Mg concentration, suggesting that increased Mg intake may counteract arterial wall hypertrophy. Neither Mg deficiency nor supplementation modified the arterial distensibility v. intra-arterial pressure curve or the Einc v. wall stress curve, indicating that dietary Mg intake did not modify wall stiffness in young rats. At mean intra-arterial pressure, the stress and Einc values were, however, significantly lower in Mg-deficient rats (P<0·05 in both cases); this finding could be related to the alteration in the geometry of the carotid artery. In conclusion, these findings suggest that Mg deficiency modifies the mechanical properties of the common carotid artery in young rats. Since Mg deficiency is considered a risk factor, these mechanical alterations could contribute to the development of atherosclerosis, hypertension and cardiovascular diseases