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Concurrent Oral 1 - Therapy of rheumatic disease : OP4. Effectiveness of Rituximab in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register (BSRBR)

Soliman, Moetaza M. ; Ashcroft, Darren M. ; Watson, Kath D. ; Lunt, Mark ; Symmons, Deborah ; Hyrich, Kimme L. ; Lachmann, H. J. ; Quartier, P. ; Hachulla, E. ; Gattorno, M. ; Cartwright, R. ; Kone-Paut, I. ; Zulian, F. ; Weisbarth-Riedel, E. ; Lepore, L. ; Hoyer, J. ; Foeldvari, I. ; Ramos, E. ; Leslie, K. ; Krammer, G. ; Preiss, R. ; Incera, E. ; Kuemmerle-Deschner, J. B. ; Hawkins, P. N. ; So, Alexander ; De Meulemeester, M. ; Pikhlak, A. ; Yücel, A. E. ; Bodalia, B. ; Kerrane, J. ; Arulmani, U. ; Richard, D. ; Murphy, V. ; Sallstig, P. ; Schlesinger, N. ; Christidis, Dimitrios ; Hassan, Nada ; Mapplebeck, Sarah ; Dasgupta, Bhaskar ; Genovese, Mark C. ; Sebba, Anthony ; Rubbert-Roth, Andrea ; Scali, Juan ; Zilberstein, Moshe ; 's Vernon, Emma ; Vollenhoven, Ronald ; Choy, Ernest ; White-Alao, Beverley ; Ibrahim, Fowzia ; Kowalczyk, Anna ; Gordon, Patrick ; Hakim, Alan ; Kitas, George ; Isenberg, David ; Griffiths, Bridget ; Lecky, Bryan ; Chakravarty, Kuntal ; Winer, John ; Danko, Katalin ; Cooper, Robert G. ; Scott, David L.

In: Rheumatology, 2011, vol. 50, p. iii31-iii34

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    Titre
    • Concurrent Oral 1 - Therapy of rheumatic disease
      OP4. Effectiveness of Rituximab in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register (BSRBR)
    Auteur
    • Soliman, Moetaza M.. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Ashcroft, Darren M.. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Watson, Kath D.. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Lunt, Mark. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Symmons, Deborah. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Hyrich, Kimme L.. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Lachmann, H. J.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Quartier, P.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Hachulla, E.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Gattorno, M.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Cartwright, R.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Kone-Paut, I.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Zulian, F.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Weisbarth-Riedel, E.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Lepore, L.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Hoyer, J.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Foeldvari, I.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Ramos, E.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Leslie, K.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Krammer, G.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Preiss, R.. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Incera, E.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Kuemmerle-Deschner, J. B.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • Hawkins, P. N.. Department of Medicine, Royal Free and University College Medical, London, United Kingdom; Universite Paris-Descartes and Unite d'Immuno-Hematologie et Rhumatologie Pediatrique, Necker-Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France; Department of Internal Medicine, Hôpital Claude Huriez CHRU, Lille Cedex, France; Department of Second Division of Pediatrics, G. Gaslini Institute, Genoa, Italy; Department of Pediatrics and Allergy and Immunology, Allergy Center at Brookstone, Columbus, GA, USA; Department of Service De Pediatrie Generale, Hôpital Kremlin Bicetre, CEREMAI, Le Kremlin Bicetre, France; S.S. Pediatric Rheumatology, University of Padova School of Medicine, Padova, Italy; Kinderklinik, Rheum. Ambulanz, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; S.C.U. Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy; Innere Medizin und Nephrologie, Universitaetsklinikum Giessen und Marburg GmbH, Marburg, Germany; Zentrum für Reumatologie, Hamburger Zentrum fuer Kinder-und Jugendrheumatologie, Hamburg, Germany; Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain; Department of Dermatology, UCSF School of Medicine, San Francisco, CA, USA; Development, Novartis Pharma AG, Basel, Switzerland; Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; Klinik fuer Kinder-und Jugendmedizin, Universitaetsklinikum, Tuebingen, Germany
    • So, Alexander. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • De Meulemeester, M.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Pikhlak, A.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Yücel, A. E.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Bodalia, B.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Kerrane, J.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Arulmani, U.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Richard, D.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Murphy, V.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Sallstig, P.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Schlesinger, N.. Deapartement de l'Appareil Locomoteur, University of Lausanne, Lausanne, Switzerland; Private Practice, Private Practice Demeulemeester, Gozée, Belgium; Clinical Research Centre Anthrology, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Baskent University Medical Faculty, Baskent University, Ankara, Turkey; General Practice, The Gables Medicentre, Coventry, United Kingdom; General Practice, Layton Medical Centre, Blackpool, United Kingdom; Integrated Health Care, Novartis Pharma AG, Basel, Switzerland; UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ,USA
    • Christidis, Dimitrios. Rheumatology, Southend University Hospital, Westcliff-On-Sea, United Kingdom
    • Hassan, Nada. Rheumatology, Southend University Hospital, Westcliff-On-Sea, United Kingdom
    • Mapplebeck, Sarah. Rheumatology, Southend University Hospital, Westcliff-On-Sea, United Kingdom
    • Dasgupta, Bhaskar. Rheumatology, Southend University Hospital, Westcliff-On-Sea, United Kingdom
    • Genovese, Mark C.. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Sebba, Anthony. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Rubbert-Roth, Andrea. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Scali, Juan. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Zilberstein, Moshe. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • 's Vernon, Emma. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Vollenhoven, Ronald. Immunology & Rheumatology, Stanford University Medical Center, Palo Alto, CA, USA; Rheumatology, University of South Florida, Palm Harbor, FL; Rheumatology, University of Cologne, Cologne, Germany; Rheumatology, Durand University Hospital, Buenos Aires, Argentina; Rheumatology, Roche, Nutley, NJ,USA; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    • Choy, Ernest. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • White-Alao, Beverley. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Ibrahim, Fowzia. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Kowalczyk, Anna. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Gordon, Patrick. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Hakim, Alan. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Kitas, George. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Isenberg, David. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Griffiths, Bridget. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Lecky, Bryan. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Chakravarty, Kuntal. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Winer, John. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Danko, Katalin. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Cooper, Robert G.. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    • Scott, David L.. Rheumatology, King's College London, London, United Kingdom; Rheumatology, Whipps Cross University Hospital, London, United Kingdom; Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom; Rheumatology, University College London Hospitals, London, United Kingdom; Musculoskeletal Unit, Freeman Hospital, Newcastle, United Kingdom; Neurology, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom; Rheumatology, Queen's Hospital, Romford, United Kingdom; Neurology, The Queen Elizabeth Hospital Neuroscience Centre, Birmingham, United Kingdom; 3 Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary; Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300341
    Summary
    Background: Rituximab (RTX) in combination with methotrexate (MTX) has been licensed since 2006 for the management of severe active rheumatoid arthritis (RA) in patients who have failed at least one anti-tumour necrosis factor (anti-TNF) therapy. Published clinical trials have demonstrated the efficacy of RTX in improving both clinical symptoms and patients' physical function. This study aimed to assess the effectiveness of RTX in RA patients treated in routine clinical practice by examining clinical and patient reported outcomes six months after receiving a first course of RTX. Methods: The analysis involved 550 RA patients registered with the BSRBR, who were starting RTX and were followed up for at least 6 months. Change in Disease Activity Score (DAS28) and European League Against Rheumatism (EULAR) response were used to assess the clinical response while change in Health Assessment Questionnaire (HAQ) score was used to assess the physical function of the patients 6 months after starting RTX. The change in DAS28 and HAQ was compared between seronegative and seropositive patients and anti-TNF naïve patients versus anti-TNF failures. The response was also compared between patients receiving RTX in combination with MTX, other non-biologic disease modifying anti-rheumatic drugs (nbDMARDs) or no nbDMARDs. Results: The mean (s.d.) age of the cohort was 59 (12) years and 78% of the patients were females. The patients had a mean (s.d.) of 15 (10) years of disease duration. 16% were biologic naïve while 84% were anti-TNF failures. 32% of the patients were seronegative and 68% were seropositive. The mean (95% CI) DAS28 at baseline was 6.2 (6.1, 6.3) which decreased to 4.8 (4.7, 4.9) at 6 months of follow up. 16% were EULAR good responders, 43% were moderate responders and 41% were non responders. The mean (95% CI) change in HAQ was −0.1 (−0.2, −0.1) (Table 1). The mean change in DAS28 was similar in seropositive and seronegative patients (p = 0.18) while the anti-TNF naïve patients showed a greater reduction in DAS28 scores than anti-TNF failures (p = 0.05). Patients receiving RTX in combination with MTX showed similar changes in DAS28 and HAQ compared to patients receiving RTX alone or with other nbDMARDs. Conclusions: RTX has proven to be effective in the routine clinical practice. Anti-TNF naïve patients seem to benefit more from RTX treatment than anti-TNF failures. Disclosure statement: The authors have declared no conflicts of interest