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Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens

Li, Yuesheng ; Sleigh, Adrian C. ; Ross, Allen G.P. ; Li, Yi ; Zhang, Xinyue ; Williams, Gail M. ; Yu, Xinling ; Tanner, Marcel ; McManus, Donald P.

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2001, vol. 95, no. 4, p. 441-448

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    Title
    • Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens
    Author
    • Li, Yuesheng. Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    • Sleigh, Adrian C.. Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    • Ross, Allen G.P.. Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    • Li, Yi. Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in the Lake Region, Hunan 414000, People's Republic of China
    • Zhang, Xinyue. Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in the Lake Region, Hunan 414000, People's Republic of China
    • Williams, Gail M.. Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    • Yu, Xinling. Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in the Lake Region, Hunan 414000, People's Republic of China
    • Tanner, Marcel. Swiss Tropical Institute, Socinstrasse 57, P. O. Box Ch-4002, Basel, Switzerland
    • McManus, Donald P.. Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2001, vol. 95, no. 4, p. 441-448. Royal Society of Tropical Medicine and Hygiene
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:300268
    Summary
    Antibody isotypic responses (IgE, IgA, IgG1, IgG2, IgG3 and IgG4) to Schistosoma japonicum antigens—adult worm (AWA), soluble egg (SEA) and the recombinant proteins TEG (22·6-kDa tegumental antigen, Sj22) and PMY (paramyosin, Sj97)—were measured (in 1998) in a cohort of 179 Chinese subjects 2 years post-treatment. Subjects in the highest intensity re-infection group (>100 eggs per gram faeces) had significantly higher levels of IgG1 and IgG4 against AWA. Analysis of IgG4/IgE ratios for AWA and SEA linked IgG4 excess to re-infection and IgE excess to non-re-infection. Two years after chemotherapeutic cure, 29 subjects, who were re-infected or never infected but highly water-exposed, were classified as epidemiologically susceptible (n = 15) or epidemiologically insusceptible to infection (n = 14). IgG4 levels against native antigens (AWA and SEA) were higher in susceptibles and IgE levels were higher in insusceptibles but antibody responses to the recombinant proteins (PMY and TEG) showed no clear pattern or difference between susceptibility groups. These and earlier findings provide evidence that immunity develops against schistosomiasis japonica in China and that susceptibility/resistance correlates with antibody isotypes against native schistosome antigens