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Shorter Survival of SDF1-3′A/3′A Homozygotes Linked to CD4+ T Cell Decrease in Advanced Human Immunodeficiency Virus Type 1 Infection

Brambilla, Andrea ; Villa, Chiara ; Rizzardi, GianPaolo ; Veglia, Fabrizio ; Ghezzi, Silvia ; Lazzarin, Adriano ; Cusini, Marco ; Muratori, Simona ; Santagostino, Elena ; Gringeri, Alessandro ; Louie, Leslie G. ; Sheppard, Haynes W. ; Poli, Guido ; Michael, Nelson L. ; Pantaleo, Giuseppe ; Vicenzi, Elisa

In: The Journal of Infectious Diseases, 2000, vol. 182, no. 1, p. 311-315

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    Titre
    • Shorter Survival of SDF1-3′A/3′A Homozygotes Linked to CD4+ T Cell Decrease in Advanced Human Immunodeficiency Virus Type 1 Infection
    Auteur
    • Brambilla, Andrea. AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    • Villa, Chiara. AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    • Rizzardi, GianPaolo. Laboratory of AIDS Immunopathogenesis, Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Veglia, Fabrizio. Biostatistics Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    • Ghezzi, Silvia. AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    • Lazzarin, Adriano. Division of Infectious Diseases, San Luigi AIDS Center, San Raffaele Scientific Institute, Milan, Italy
    • Cusini, Marco. STD Clinic, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital and University of Milan, Milan, Italy
    • Muratori, Simona. STD Clinic, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital and University of Milan, Milan, Italy
    • Santagostino, Elena. "A. Bianchi Bonomi” Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital and University of Milan, Milan, Italy
    • Gringeri, Alessandro. "A. Bianchi Bonomi” Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital and University of Milan, Milan, Italy
    • Louie, Leslie G.. School of Public Health, University of California, Berkeley, California
    • Sheppard, Haynes W.. California Department of Health Services, Berkeley, California
    • Poli, Guido. AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    • Michael, Nelson L.. Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland
    • Pantaleo, Giuseppe. Laboratory of AIDS Immunopathogenesis, Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Vicenzi, Elisa. AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2000, vol. 182, no. 1, p. 311-315. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300128
    Summary
    The SDF-1 3′A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3′A/3′A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts <200 was observed. The relative hazards for SDF1-3′A/3′A homozygotes, compared with heterozygotes and wild-type homozygotes were 2.16 (P = .0047), for time from diagnosis according to the 1993 Centers for Disease Control and Prevention AIDS case definition (AIDS-'93) to death, and 3.43 (P = .0001), for time from CD4+ T cells <200 to death. Because no difference in survival was observed after diagnosis according to AIDS-'87, the association of the SDF1-3′A/3′A genotype with the accelerated progression of late-stage HIV-1 disease appears to be explained for the most part by the loss of CD4+ T lymphocytes