Fulltext

Response to Treatment and Disease Progression Linked to CD4+ T Cell Surface CC Chemokine Receptor 5 Density in Human Immunodeficiency Virus Type 1 Vertical Infection

Gervaix, Alain ; Nicolas, Joelle ; Portales, Pierre ; Posfay-Barbe, Klara ; Wyler, Claire-Anne ; Segondy, Michel ; Avinens, Odile ; Siegrist, Claire-Anne ; Clot, Jacques ; Eliaou, Jean-François ; Astruc, Jacques ; Corbeau, Pierre

In: The Journal of Infectious Diseases, 2002, vol. 185, no. 8, p. 1055-1061

Add to personal list
    Title
    • Response to Treatment and Disease Progression Linked to CD4+ T Cell Surface CC Chemokine Receptor 5 Density in Human Immunodeficiency Virus Type 1 Vertical Infection
    Author
    • Gervaix, Alain. Département de Pédiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland
    • Nicolas, Joelle. Service de Pédiatrie III, Hôpital Arnaud de Villeneuve, Montpellier, France
    • Portales, Pierre. Laboratoire d'Immunologie, Montpellier, France
    • Posfay-Barbe, Klara. Département de Pédiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland
    • Wyler, Claire-Anne. Département de Pédiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland
    • Segondy, Michel. Laboratoire de Virologie, Hôpital Saint Eloi, Montpellier, France
    • Avinens, Odile. Laboratoire d'Immunologie, Montpellier, France
    • Siegrist, Claire-Anne. Département de Pédiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland
    • Clot, Jacques. Laboratoire d'Immunologie, Montpellier, France
    • Eliaou, Jean-François. Laboratoire d'Immunologie, Montpellier, France
    • Astruc, Jacques. Service de Pédiatrie III, Hôpital Arnaud de Villeneuve, Montpellier, France
    • Corbeau, Pierre. Laboratoire d'Immunologie, Montpellier, France
    Document Type
    • Postprint
    Language
    • English
    Published in
    • The Journal of Infectious Diseases, 2002, vol. 185, no. 8, p. 1055-1061. University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:299941
    Summary
    The factors governing interindividual variability in disease progression among children vertically infected with human immunodeficiency virus type 1 (HIV-1) remain unclear. Because it has recently been shown in infected adults that the density of CC chemokine receptor 5 (CCR5) molecules at the surface of nonactivated (human leukocyte antigen [HLA]-DR-) CD4+ T cells correlates with disease progression, the same correlation was sought in children. HLA-DR-CD4+ T cell surface CCR5 density was constant over time and correlated with the bioclinical stage and with the CD4 cell slope observed before antiretroviral treatment. In addition, CCR5 density was negatively correlated with the intensity of the decrease in viremia during antiretroviral therapy and was positively correlated with CD4 cell slope since birth. These results are compatible with the hypothesis that CCR5 density is a key factor governing disease progression in pediatric HIV-1 infection and, thereby, an indicator of prognosis. Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in children