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Caloric Restriction Affects Liver Microsomal Monooxygenases Differentially in Aging Male Rats

Schmucker, Douglas L. ; Wang, Rose K. ; Snyder, David ; Strobel, Henry ; Marti, Ulrich

In: Journal of Gerontology, 1991, vol. 46, no. 1, p. B23-B27

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    Title
    • Caloric Restriction Affects Liver Microsomal Monooxygenases Differentially in Aging Male Rats
    Author
    • Schmucker, Douglas L.. Cell Biology and Aging Section, VA Medical Center, and The University of California San Francisco
    • Wang, Rose K.. Cell Biology and Aging Section, VA Medical Center, and The University of California San Francisco
    • Snyder, David. Lobund Laboratory, University of Notre Dame
    • Strobel, Henry. University of Texas Health Science Center Houston
    • Marti, Ulrich. Department of Clinical Pharmacology, University of Berne Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Gerontology, 1991, vol. 46, no. 1, p. B23-B27. The Gerontological Society of America
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:299657
    Summary
    Caloric restriction (CR) extends life span and retards the onset of physiological changes and pathologies associated with aging, but the underlying mechanisms remain unresolved. This study demonstrates that CR postpones the documented age-related declines in and/or enhances the activity and microsomal concentrations of several liver monooxygenases in male rats, i.e., NADPH cytochrome P-450 reductase, total cytochromes P-450. However, the relative concentration of cytochrome P-450b+c did not exhibit statistically significant changes, whereas another isozyme, the male specific P-450h, declined significantly in both ad libitum-fed and CR rats as a function of increasing age. While CR appears to retard age-associated changes in certain liver enzymes, this effect is by no means universal. The hepatic monooxygenases constitute a well-characterized enzyme system in which to examine the perturbation of the aging process by CR