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BAFF production by antigen‐presenting cells provides T cell co‐stimulation

Huard, Bertrand ; Arlettaz, Lionel ; Ambrose, Christine ; Kindler, Vincent ; Mauri, Davide ; Roosnek, Eddy ; Tschopp, Jürg ; Schneider, Pascal ; French, Lars E.

In: International Immunology, 2004, vol. 16, no. 3, p. 467-475

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    Titre
    • BAFF production by antigen‐presenting cells provides T cell co‐stimulation
    Auteur
    • Huard, Bertrand. Department of Dermatology, University Medical Center, 1 rue Michel‐Servet, 7211 Geneva 4, Switzerland
    • Arlettaz, Lionel. Division of Immunology and Allergology, University Hospital, Geneva 7211, Switzerland
    • Ambrose, Christine. Department of Dermatology, University Medical Center, 1 rue Michel‐Servet, 7211 Geneva 4, Switzerland
    • Kindler, Vincent. Division of Hematology, University Hospital, Geneva 1211, Switzerland
    • Mauri, Davide. Apotech Corp., Epalinges 1066, Switzerland
    • Roosnek, Eddy. Division of Immunology and Allergology, University Hospital, Geneva 7211, Switzerland
    • Tschopp, Jürg. Institute of Biochemistry, Lausanne University, Epalinges 1066, Switzerland
    • Schneider, Pascal. Institute of Biochemistry, Lausanne University, Epalinges 1066, Switzerland
    • French, Lars E.. Department of Dermatology, University Medical Center, 1 rue Michel‐Servet, 7211 Geneva 4, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • International Immunology, 2004, vol. 16, no. 3, p. 467-475. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299340
    Summary
    The B cell‐activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co‐stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co‐stimulatory function. BAFF is produced by antigen‐presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up‐regulates BAFF production in these cells. A low level of BAFF transcription, up‐regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC