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Changing species distribution and antimicrobial susceptibility pattern of Shigella over a 29-year period (1980-2008)

KHATUN, F. ; FARUQUE, A. S. G. ; KOECK, J. L. ; OLLIARO, P. ; MILLET, P. ; PARIS, N. ; MALEK, M. A. ; SALAM, M. A. ; LUBY, S.

In: Epidemiology and Infection, 2011, vol. 139, no. 3, p. 446-452

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    Titre
    • Changing species distribution and antimicrobial susceptibility pattern of Shigella over a 29-year period (1980-2008)
    Auteur
    • KHATUN, F.. International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
    • FARUQUE, A. S. G.. International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
    • KOECK, J. L.. Centre René Labusquière, Université Victor Segalen Bordeaux 2, Bordeaux, France
    • OLLIARO, P.. UNICEF/UNDP/WB/WHO Special Programme for Research & Training in Tropical Diseases (TDR), Geneva, Switzerland
    • MILLET, P.. Centre René Labusquière, Université Victor Segalen Bordeaux 2, Bordeaux, France
    • PARIS, N.. Société OPTIMA, Merignac, France
    • MALEK, M. A.. International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
    • SALAM, M. A.. International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
    • LUBY, S.. International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Epidemiology and Infection, 2011, vol. 139, no. 3, p. 446-452. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298985
    Summary
    We studied changes in species distribution and antimicrobial resistance patterns of Shigella during 1980-2008, using the Diarrhoeal Diseases Surveillance system of Dhaka Hospital of ICDDR,B. In hospitalized patients Shigella prevalence decreased steadily from 8-12% in the 1980s to 3% in 2008. Endemic S. flexneri was the most commonly isolated species (54%). Epidemic S. dysenteriae type 1 had two peaks in 1984 and 1993, but was not found after 2000, except for one case in 2004. The therapeutic options are now limited: in 2008 a total of 33% of S. flexneri were resistant to ciprofloxacin and 57% to mecillinam. In the <5 years age group, severely underweight, wasted and stunted children were more at risk of shigellosis compared to well-nourished children (P<0·001). Although hospitalization for Shigella diarrhoea is decreasing, the high levels of antimicrobial resistance and increased susceptibility of malnourished children continue to pose an ongoing risk