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HIV-Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4+ T Cells in Relation to HIV RNA Load

Oxenius, Annette ; Price, David A. ; Hersberger, Martin ; Schlaepfer, Erika ; Weber, Rainer ; Weber, Markus ; Kundig, Thomas M. ; Böni, Jürg ; Joller, Helen ; Phillips, Rodney E. ; Flepp, Markus ; Opravil, Milos ; Speck, Roberto F.

In: Journal of Infectious Diseases, 2004, vol. 189, no. 7, p. 1199-1208

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    Title
    • HIV-Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4+ T Cells in Relation to HIV RNA Load
    Author
    • Oxenius, Annette. Institute for Microbiology, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland
    • Price, David A.. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    • Hersberger, Martin. nstitute of Clinical Chemistry, Zurich, Switzerland
    • Schlaepfer, Erika. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    • Weber, Markus. Clinic of Visceral and Transplantation Surgery, University Hospital of Zurich, Zurich, Switzerland
    • Kundig, Thomas M.. Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    • Böni, Jürg. 7Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
    • Joller, Helen. Clinical Immunology, Department of Medicine,, University Hospital of Zurich, Zurich, Switzerland
    • Phillips, Rodney E.. Nuffield Department of Medicine, John Radcliffe Hospital and the Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    • Flepp, Markus. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    • Opravil, Milos. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    • Speck, Roberto F.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 2004, vol. 189, no. 7, p. 1199-1208. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:298698
    Summary
    The average time between infection with human immunodeficiency virus (HIV) and development of acquired immune deficiency syndrome is ∼8 years. However, progression rates vary widely, depending on several determinants, including HIV-specific immunity, host genetic factors, and virulence of the infecting strain. In untreated HIV-infected patients with different progression rates, we examined HIV-specific T cell responses in combination with host genetic markers, such as chemokine/chemokine-receptor (CCR) polymorphisms and human leukocyte antigen (HLA) genotypes. HIV-specific CD4+ T cell responses and, to a lesser extent, HIVspecific CD8+ T cell responses were inversely correlated with progression rate. Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression