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Human pharmacology of 5-epi-sisomicin (Sch 22591) following intramuscular administration

Blaser, J. ; M¨nch, R. ; Lüthy, R.

In: Journal of Antimicrobial Chemotherapy, 1987, vol. 19, no. 2, p. 233-238

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    Titre
    • Human pharmacology of 5-epi-sisomicin (Sch 22591) following intramuscular administration
    Auteur
    • Blaser, J.. Department of Medicine, University Hospital, Zürich, Switzerland
    • M¨nch, R.. Department of Medicine, University Hospital, Zürich, Switzerland
    • Lüthy, R.. Department of Medicine, University Hospital, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1987, vol. 19, no. 2, p. 233-238. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298600
    Summary
    5-epi-sisomicin was given as a single intramuscular injection of 1 mg/kg to six healthy male adults. Serum peak concentrations averaged 3.07 mg/l, the mean elimination half life was 179 min and the mean 24 h urinary recovery was 85.3%. Local and systemic tolerance was good