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TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6

Nussler, Andreas ; Pied, Sylviane ; Goma, Joseph ; Rénia, Laurent ; Miltgen, François ; Grau, Georges E. ; Mazier, Dominique

In: International Immunology, 1991, vol. 3, no. 4, p. 317-321

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    Titre
    • TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6
    Auteur
    • Nussler, Andreas. INSERM U313, Groupe Pitié-Salpêtrière, 911Bd de l'H;ôpital, 75013 Paris, France, 61, rue Buffon, 75006 Paris, France, Switzerland
    • Pied, Sylviane. INSERM U313, Groupe Pitié-Salpêtrière, 911Bd de l'H;ôpital, 75013 Paris, France, 61, rue Buffon, 75006 Paris, France, Switzerland
    • Goma, Joseph. INSERM U313, Groupe Pitié-Salpêtrière, 911Bd de l'H;ôpital, 75013 Paris, France, 61, rue Buffon, 75006 Paris, France, Switzerland
    • Rénia, Laurent. INSERM U313, Groupe Pitié-Salpêtrière, 911Bd de l'H;ôpital, 75013 Paris, France, 61, rue Buffon, 75006 Paris, France, Switzerland
    • Miltgen, François. Museum National d'Histoire Naturelle 61, rue Buffon, 75006 Paris, France
    • Grau, Georges E.. WHO-IRTC, Dept of Pathology, University of Geneva Switzerland
    • Mazier, Dominique. INSERM U313, Groupe Pitié-Salpêtrière, 911Bd de l'H;ôpital, 75013 Paris, France, 61, rue Buffon, 75006 Paris, France, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • International Immunology, 1991, vol. 3, no. 4, p. 317-321. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298509
    Summary
    We examined the capacity of murine recombinant tumor necrosis factor (rmTNF) to induce an inhibitory effect at the hepatic stage on malaria induced by Plasmodium yoelll sporozoitea. When injected three times, 1.0 μg of rmTNF was found to protect 78% of mice against a sporozoite challenge. In contrast, whatever the dose and the schedule of administration, no inhibition was observed when purified hepatocyte cultures were infected with P. yoelii. The addition of non-parenchymal hepatic cells to hepatocyte cultures restored the capacity of TNF to modulate hepatic stage development, leading to up to 44% inhibition. Antibodies to interleukin 6 reversed the anti-parasite activity in the co-culture system