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Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type

Camenzind, Edoardo ; Boersma, Eric ; Wijns, William ; Mauri, Laura ; Rademaker-Havinga, Tessa ; Ordoubadi, Farzin Fath ; Suttorp, Maarten J. ; Al Kurdi, Mohammad ; Steg, Ph Gabriel ; Camenzind, E. ; Mauri, L. ; O'Neill, W. ; Serruys, P W. ; Steg, PhG ; Wijns, W. ; Verheugt, FWA ; Bertrand, ME ; Califf, R. ; DeMets, D. ; Wallentin, L. ; Bocksch, W. ; Bosmans, J. ; Garcia, H. ; Garg, S. ; Hanet, C. ; Herrman, J-PR ; Kelbaek, H. ; Mc Fadden, E. ; Radke, PW ; Rutsch, W. ; Tilsted, HH ; Wykrzykowska, J. ; Alvarez, C. ; Rodriguez, A. ; Meredith, I. ; Muller, D. ; Whitbourn, R. ; Worthley, S. ; Whelan, A. ; Walters, D. ; Shetty, S. ; New, G. ; Cox, S. ; Batra, R. ; van Gaal, W. ; Bellamy, G. ; Mayr, H. ; Heigert, M. ; Huber, K. ; Leisch, F. ; Desmet, W. ; Boland, J. ; Schroeder, E. ; Chenu, P. ; Legrand, V. ; Labinaz, M. ; Teefy, P. ; Bertrand, O. ; Gao, R. ; Ge, J. ; Kala, P. ; Cervinka, P. ; Ureña, P. ; Hartikainen, J. ; Steg, G. ; Fajadet, J. ; Carrie, D. ; Gilard, M. ; Barragan, P. ; Lablanche, J-M ; Koning, R. ; Eltchaninoff, H. ; Darremont, O. ; Leroy, F. ; Bertrand, B. ; Robert, G. ; Schiele, F. ; Chassaing, S. ; Bressollette, E. ; Brunel, P. ; Quilliet, L. ; Brunet, J. ; Pansieri, M. ; Sideris, G. ; Stratiev, V. ; Teiger, E. ; Lebreton, H. ; Bonnet, J-L ; Karsenty, B. ; Delarche, N. ; Lusson, J-R ; Cassagnes, J. ; Brachmann, J. ; Kurowski, V. ; Buerke, M. ; Schieffer, B. ; Scholtz, W. ; Wiemer, M. ; Fichtlscherer, S. ; Schächinger, V. ; Kupatt, C. ; Boekstegers, P. ; Genth-Zotz, S. ; Bode, C. ; Frey, N. ; Neumann, F-J ; Witzenbichler, B. ; Pels, K. ; Strasser, R. ; Kuck, K-H ; Hauptmann, K-E ; Baldus, S. ; Heitzer, T. ; Haude, M. ; Hoffmann, E. ; Jung, W. ; Hoffmann, S. ; Schmitt, C. ; Dissmann, M. ; Pauschinger, M. ; Werner, G. ; Braun-Delleus, R. ; Burkhardt, D. ; Manz, M. ; Voudris, V. ; Sionis, D. ; Kang-Yin, M-L ; Tse, T-S ; Merkely, B. ; Mehta, A. ; Parikh, K. ; Kumar, V. ; Chandra, P. ; Rath, P. ; Hiremath, S. ; Crean, P. ; Daly, K. ; Kornowski, R. ; Kerner, A. ; Mosseri, M. ; Jafari, G. ; Giudice, P. ; Trani, C. ; Manari, A. ; Prati, F. ; Pangrazi, A. ; Bolognese, L. ; Jeong, M-H ; Kim, M-Y ; Kim, H-S ; Park, S-J ; Erglis, A. ; Kalnins, A. ; Wagner, D. ; Zambahari, R. ; Ong, T-K ; Sim, K. ; den Heijer, P. ; Appelman, Y. ; Suttorp, M-J ; de Smet, B. ; Koolen, J. ; Stella, P. ; Harding, S. ; Warwick, J. ; Maslowski, A. ; Abernethy, M. ; Devlin, G. ; Rotevatn, S. ; Myreng, Y. ; Ciecwierz, D. ; Peruga, J. ; Reczuch, K. ; Campante Teles, R. ; Farto, P. ; Abreu, E. ; Leitão-Marques, A. ; Pereira, H. ; Vinereanu, D. ; Alkasab, S. ; Mhish, H. ; Al Kurdi, M. ; Al Turki, F. ; Wong, P. ; Teo, S-G ; Goicolea Ruigomez, F-J ; Valdés Chávarri, M. ; Bethencourt Gonzalez, A. ; Iñiguez Romo, A. ; López Minguez, J. ; Hernández García, J-M ; Diaz Fernández, J. ; Ruiz Salmeron, R. ; Martinez Elbal, L. ; Zueco, J. ; López-Palop, RF ; Melgares, R. ; Diderholm, E. ; Kåregren, A. ; Herterich, O. ; Olivencrona, G. ; Fröbert, O. ; Roffi, M. ; Verin, V. ; Girod, G. ; Vuilliomenet, A. ; Hsieh, I-C ; Wu, C-J ; Gershlick, A. ; Densem, C. ; Doshi, S. ; Manoharan, G. ; McCarthy, P. ; De Belder, M. ; Mills, J. ; Fath-Ordoubadi, F. ; Simpson, I. ; Greenwood, J. ; Chamberlain-Webber, R. ; Khan, Z. ; Cotton, J. ; Gunning, M. ; Smith, D. ; Talwar, S. ; Holmberg, S. ; Purcell, I. ; Anderson, R. ; Alamgir, F. ; Beatt, K. ; Kelly, P. ; Moussavian, M. ; Aji, J. ; Prashad, R. ; Zankar, A. ; Banerjee, S. ; Lewis, S. ; McLaurin, B. ; Douglas, J. ; Brener, S. ; Gupta, A. ; Walters, L. ; Driesman, M. ; Aycock, R. ; Mego, C. ; Fisher, D. ; Frankel, R. ; Satler, L.

In: European Heart Journal, 2014, vol. 35, no. 29, p. 1932-1948

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    Titre
    • Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type
    Auteur
    • Camenzind, Edoardo. University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, Switzerland
    • Boersma, Eric. Erasmus Medical Center, Rotterdam, the Netherlands
    • Wijns, William. Cardiovascular Center, OLV Hospital, Aalst, Belgium
    • Mauri, Laura. Brigham and Women's Hospital, Boston, MA, USA
    • Rademaker-Havinga, Tessa. Cardialysis, Rotterdam, the Netherlands
    • Ordoubadi, Farzin Fath. Manchester Royal Infirmary Hospital, Manchester, UK
    • Suttorp, Maarten J.. St Antonius Ziekehuis, Nieuwegein, the Netherlands
    • Al Kurdi, Mohammad. Prince Salman Cardiac Center, King Fahd Medical City, Riyad, Saudi Arabia
    • Steg, Ph Gabriel. Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France
    • Camenzind, E.
    • Mauri, L.
    • O'Neill, W.
    • Serruys, P W.
    • Steg, PhG
    • Wijns, W.
    • Verheugt, FWA
    • Bertrand, ME
    • Califf, R.
    • DeMets, D.
    • Wallentin, L.
    • Bocksch, W.
    • Bosmans, J.
    • Garcia, H.
    • Garg, S.
    • Hanet, C.
    • Herrman, J-PR
    • Kelbaek, H.
    • Mc Fadden, E.
    • Radke, PW
    • Rutsch, W.
    • Tilsted, HH
    • Wykrzykowska, J.
    • Alvarez, C.
    • Rodriguez, A.
    • Meredith, I.
    • Muller, D.
    • Whitbourn, R.
    • Worthley, S.
    • Whelan, A.
    • Walters, D.
    • Shetty, S.
    • New, G.
    • Cox, S.
    • Batra, R.
    • van Gaal, W.
    • Bellamy, G.
    • Mayr, H.
    • Heigert, M.
    • Huber, K.
    • Leisch, F.
    • Desmet, W.
    • Boland, J.
    • Schroeder, E.
    • Chenu, P.
    • Legrand, V.
    • Labinaz, M.
    • Teefy, P.
    • Bertrand, O.
    • Gao, R.
    • Ge, J.
    • Kala, P.
    • Cervinka, P.
    • Ureña, P.
    • Hartikainen, J.
    • Steg, G.
    • Fajadet, J.
    • Carrie, D.
    • Gilard, M.
    • Barragan, P.
    • Lablanche, J-M
    • Koning, R.
    • Eltchaninoff, H.
    • Darremont, O.
    • Leroy, F.
    • Bertrand, B.
    • Robert, G.
    • Schiele, F.
    • Chassaing, S.
    • Bressollette, E.
    • Brunel, P.
    • Quilliet, L.
    • Brunet, J.
    • Pansieri, M.
    • Sideris, G.
    • Stratiev, V.
    • Teiger, E.
    • Lebreton, H.
    • Bonnet, J-L
    • Karsenty, B.
    • Delarche, N.
    • Lusson, J-R
    • Cassagnes, J.
    • Brachmann, J.
    • Kurowski, V.
    • Buerke, M.
    • Schieffer, B.
    • Scholtz, W.
    • Wiemer, M.
    • Fichtlscherer, S.
    • Schächinger, V.
    • Kupatt, C.
    • Boekstegers, P.
    • Genth-Zotz, S.
    • Bode, C.
    • Frey, N.
    • Neumann, F-J
    • Witzenbichler, B.
    • Pels, K.
    • Strasser, R.
    • Kuck, K-H
    • Hauptmann, K-E
    • Baldus, S.
    • Heitzer, T.
    • Haude, M.
    • Hoffmann, E.
    • Jung, W.
    • Hoffmann, S.
    • Schmitt, C.
    • Dissmann, M.
    • Pauschinger, M.
    • Werner, G.
    • Braun-Delleus, R.
    • Burkhardt, D.
    • Manz, M.
    • Voudris, V.
    • Sionis, D.
    • Kang-Yin, M-L
    • Tse, T-S
    • Merkely, B.
    • Mehta, A.
    • Parikh, K.
    • Kumar, V.
    • Chandra, P.
    • Rath, P.
    • Hiremath, S.
    • Crean, P.
    • Daly, K.
    • Kornowski, R.
    • Kerner, A.
    • Mosseri, M.
    • Jafari, G.
    • Giudice, P.
    • Trani, C.
    • Manari, A.
    • Prati, F.
    • Pangrazi, A.
    • Bolognese, L.
    • Jeong, M-H
    • Kim, M-Y
    • Kim, H-S
    • Park, S-J
    • Erglis, A.
    • Kalnins, A.
    • Wagner, D.
    • Zambahari, R.
    • Ong, T-K
    • Sim, K.
    • den Heijer, P.
    • Appelman, Y.
    • Suttorp, M-J
    • de Smet, B.
    • Koolen, J.
    • Stella, P.
    • Harding, S.
    • Warwick, J.
    • Maslowski, A.
    • Abernethy, M.
    • Devlin, G.
    • Rotevatn, S.
    • Myreng, Y.
    • Ciecwierz, D.
    • Peruga, J.
    • Reczuch, K.
    • Campante Teles, R.
    • Farto, P.
    • Abreu, E.
    • Leitão-Marques, A.
    • Pereira, H.
    • Vinereanu, D.
    • Alkasab, S.
    • Mhish, H.
    • Al Kurdi, M.
    • Al Turki, F.
    • Wong, P.
    • Teo, S-G
    • Goicolea Ruigomez, F-J
    • Valdés Chávarri, M.
    • Bethencourt Gonzalez, A.
    • Iñiguez Romo, A.
    • López Minguez, J.
    • Hernández García, J-M
    • Diaz Fernández, J.
    • Ruiz Salmeron, R.
    • Martinez Elbal, L.
    • Zueco, J.
    • López-Palop, RF
    • Melgares, R.
    • Diderholm, E.
    • Kåregren, A.
    • Herterich, O.
    • Olivencrona, G.
    • Fröbert, O.
    • Roffi, M.
    • Verin, V.
    • Girod, G.
    • Vuilliomenet, A.
    • Hsieh, I-C
    • Wu, C-J
    • Gershlick, A.
    • Densem, C.
    • Doshi, S.
    • Manoharan, G.
    • McCarthy, P.
    • De Belder, M.
    • Mills, J.
    • Fath-Ordoubadi, F.
    • Simpson, I.
    • Greenwood, J.
    • Chamberlain-Webber, R.
    • Khan, Z.
    • Cotton, J.
    • Gunning, M.
    • Smith, D.
    • Talwar, S.
    • Holmberg, S.
    • Purcell, I.
    • Anderson, R.
    • Alamgir, F.
    • Beatt, K.
    • Kelly, P.
    • Moussavian, M.
    • Aji, J.
    • Prashad, R.
    • Zankar, A.
    • Banerjee, S.
    • Lewis, S.
    • McLaurin, B.
    • Douglas, J.
    • Brener, S.
    • Gupta, A.
    • Walters, L.
    • Driesman, M.
    • Aycock, R.
    • Mego, C.
    • Fisher, D.
    • Frankel, R.
    • Satler, L.
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • European Heart Journal, 2014, vol. 35, no. 29, p. 1932-1948. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298138
    Summary
    Aim To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES). Methods and results Of 8709 patients in PROTECT, 4357 were randomized to E-ZES and 4352 to C-SES. Aspirin was to be given indefinitely, and clopidogrel/ticlopidine for ≥3 months or up to 12 months after implantation. Main outcome measures were definite or probable stent thrombosis at 3 years. Multivariable Cox regression analysis was applied, with stent type, DAPT, and their interaction as the main outcome determinants. Dual antiplatelet therapy adherence remained the same in the E-ZES and C-SES groups (79.6% at 1 year, 32.8% at 2 years, and 21.6% at 3 years). We observed a statistically significant (P = 0.0052) heterogeneity in treatment effect of stent type in relation to DAPT. In the absence of DAPT, stent thrombosis was lower with E-ZES vs. C-SES (adjusted hazard ratio 0.38, 95% confidence interval 0.19, 0.75; P = 0.0056). In the presence of DAPT, no difference was found (1.18; 0.79, 1.77; P = 0.43). Conclusion A strong interaction was observed between drug-eluting stent type and DAPT use, most likely prompted by the vascular healing response induced by the implanted DES system. These results suggest that the incidence of stent thrombosis in DES trials should not be evaluated independently of DAPT use, and the optimal duration of DAPT will likely depend upon stent type (Clinicaltrials.gov number NCT00476957)