Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials

Huttner, Angela ; Verhaegh, Els M. ; Harbarth, Stephan ; Muller, Anouk E. ; Theuretzbacher, Ursula ; Mouton, Johan W.

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 9, p. 2456-2464

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    Summary
    The available evidence supports first-line treatment of lower urinary tract infections with nitrofurantoin as clinical efficacy is similar to that seen for trimethoprim/sulfamethoxazole, ciprofloxacin and amoxicillin, rates of microbiological cure are good, short- term toxicity is generally mild and acquired resistance is still relatively rare