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Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL in 2009: a French nationwide study

Assoumou, Lambert ; Descamps, Diane ; Yerly, Sabine ; Dos Santos, Georges ; Marcelin, Anne-Geneviève ; Delaugerre, Constance ; Morand-Joubert, Laurence ; Ruffault, Annick ; Izopet, Jacques ; Plantier, Jean-Christophe ; Pakianather, Sophie ; Montes, Brigitte ; Chaix, Marie-Laure ; Wirden, Marc ; Costagliola, Dominique ; Masquelier, Bernard

In: Journal of Antimicrobial Chemotherapy, 2013, vol. 68, no. 6, p. 1400-1405

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    Titre
    • Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL in 2009: a French nationwide study
    Auteur
    • Assoumou, Lambert. INSERM, U 943, Paris, France
    • Descamps, Diane. AP-HP, Hôpital Bichat-Claude Bernard and EA4409 Université Paris-Diderot, Paris, France
    • Yerly, Sabine. Laboratoire de Virologie, Hôpitaux Universitaires de Genève, Genève, Switzerland
    • Dos Santos, Georges. Laboratoire de Virologie, EA4537, CHU de Fort de France, Martinique, France
    • Marcelin, Anne-Geneviève. INSERM, U 943, Paris, France
    • Delaugerre, Constance. AP-HP, Hôpital Saint-Louis, Paris, France
    • Morand-Joubert, Laurence. INSERM, U 943, Paris, France
    • Ruffault, Annick. CHU de Rennes, Rennes, France
    • Izopet, Jacques. CHU de Toulouse, Toulouse, France
    • Plantier, Jean-Christophe. CHU de Rouen, Rouen, France
    • Pakianather, Sophie. INSERM, U 943, Paris, France
    • Montes, Brigitte. CHU de Montpellier, Montpellier, France
    • Chaix, Marie-Laure. Université Paris Descartes, Pres Sorbonne, Paris Cité, AP-HP, Hôpital Necker, Paris, France
    • Wirden, Marc. INSERM, U 943, Paris, France
    • Costagliola, Dominique. INSERM, U 943, Paris, France
    • Masquelier, Bernard. Laboratoire de Virologie, CHU de Bordeaux and Univ. Bordeaux, Microbiologie fondamentale et Pathogénicité, UMR 5234, F-33000 Bordeaux, France
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 2013, vol. 68, no. 6, p. 1400-1405. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297279
    Summary
    Background Surveillance of HIV-1 drug resistance in treated patients with plasma viral load (VL) >50 copies/mL. Methods The protease and reverse transcriptase (RT) genes were systematically sequenced in samples from 756 patients with VL >50 copies/mL in 2009. The genotyping results were interpreted for each antiretroviral drug (ARV) by using the ANRS algorithm v21. Weighted analyses were used to derive representative estimates of percentages of patients. Prevalence rates were compared with those obtained in 2004 among patients with VL >1000 copies/mL. Results Sequences were obtained for 506 patients. Sequencing was successful in 45%, 80% and 96% of samples with VL of 51-500, 501-1000 and >1000 copies/mL, respectively. Resistance or possible resistance to at least one ARV was observed in 59% of samples. Overall, 0.9% of samples contained viruses resistant to all drugs belonging to at least three drug classes. All resistance prevalence rates were significantly lower in 2009 than in 2004. Conclusion In France, where 86% of patients were receiving combination antiretroviral therapy in 2009, only 15.0% of patients had a VL >50 copies/mL, suggesting that only 8.9% of treated patients could potentially transmit resistant viruses. Only 0.08% of patients harboured viruses fully resistant to at least three antiretroviral drug classes. Further studies are needed to determine whether resistance continues to decline over time