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DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation

Minten, Carsten ; Alt, Carsten ; Gentner, Melanie ; Frei, Elisabeth ; Deutsch, Urban ; Lyck, Ruth ; Schaeren-Wiemers, Nicole ; Rot, Antal ; Engelhardt, Britta

In: Brain, 2014, vol. 137, no. 5, p. 1454-1469

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    Title
    • DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation
    Author
    • Minten, Carsten. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    • Alt, Carsten. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    • Gentner, Melanie. 2 Neurobiology, Department of Biomedicine, University Hospital Basel, University Basel, Switzerland
    • Frei, Elisabeth. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    • Deutsch, Urban. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    • Lyck, Ruth. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    • Schaeren-Wiemers, Nicole. 2 Neurobiology, Department of Biomedicine, University Hospital Basel, University Basel, Switzerland
    • Rot, Antal. 3 MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, UK
    • Engelhardt, Britta. 1 Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:297224
    Summary
    Trafficking of T cells into the CNS is a pathophysiological hallmark of multiple sclerosis. Using an invitro model of the blood-brain barrier, Minten etal. reveal that the atypical chemokine receptor DARC shuttles inflammatory chemokines across the barrier, where they contribute to immune cell trafficking into the brain