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Tuberculosis Diagnostics and Biomarkers: Needs, Challenges, Recent Advances, and Opportunities

McNerney, Ruth ; Maeurer, Markus ; Abubakar, Ibrahim ; Marais, Ben ; Mchugh, Timothy D. ; Ford, Nathan ; Weyer, Karin ; Lawn, Steve ; Grobusch, Martin P. ; Memish, Ziad ; Squire, S. Bertel ; Pantaleo, Giuseppe ; Chakaya, Jeremiah ; Casenghi, Martina ; Migliori, Giovanni-Batista ; Mwaba, Peter ; Zijenah, Lynn ; Hoelscher, Michael ; Cox, Helen ; Swaminathan, Soumya ; Kim, Peter S. ; Schito, Marco ; Harari, Alexandre ; Bates, Matthew ; Schwank, Samana ; O'Grady, Justin ; Pletschette, Michel ; Ditui, Lucica ; Atun, Rifat ; Zumla, Alimuddin

In: Journal of Infectious Diseases, 2012, vol. 205, p. S147-S158

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    Title
    • Tuberculosis Diagnostics and Biomarkers: Needs, Challenges, Recent Advances, and Opportunities
    Author
    • McNerney, Ruth. Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    • Maeurer, Markus. Department of Microbiology, Tumor and Cell Biology
    • Abubakar, Ibrahim. Tuberculosis Section, Health Protection Services, Health Protection Agency, Colindale, London, United Kingdom
    • Marais, Ben. Sydney Emerging Infectious Diseases and Biosecurity Institute
    • Mchugh, Timothy D.. University College London Medical School, Centre for Clinical Microbiology, University College London, United Kingdom
    • Ford, Nathan. South Africa Unit, Médecins Sans Frontières, Cape Town
    • Weyer, Karin. TB Diagnostics and Laboratory Strengthening, Stop TB Department, World Health Organization, Geneva, Switzerland
    • Lawn, Steve. The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    • Grobusch, Martin P.. Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    • Memish, Ziad. Ministry of Health and College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
    • Squire, S. Bertel. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom
    • Pantaleo, Giuseppe. Division of Immunology and Allergy and Swiss Vaccine Research Institute, Centre Hospitalier Universitaire Vaudois, Universitiy of Lausanne, Switzerland
    • Chakaya, Jeremiah. Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Africa
    • Casenghi, Martina. South Africa Unit, Médecins Sans Frontières, Cape Town
    • Migliori, Giovanni-Batista. WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy
    • Mwaba, Peter. Ministry of Health and the UNZA-UCLMS Project, Lusaka, Zambia
    • Zijenah, Lynn. Department of Immunology, College of Health Sciences University of Zimbabwe, Harare
    • Hoelscher, Michael. International Medicine and Public Health, Department for Infectious Diseases and Tropical Medicine, University of Munich, Germany
    • Cox, Helen. South Africa Unit, Médecins Sans Frontières, Cape Town
    • Swaminathan, Soumya. National Institute for Research in Tuberculosis, Chennai, India
    • Kim, Peter S.. TB Team, Division of Acquired Immunodeficiency Syndrome, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    • Schito, Marco. Vaccine Clinical Research Branch, Division of Acquired Immunodeficiency Syndrome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    • Harari, Alexandre. Division of Immunology and Allergy and Swiss Vaccine Research Institute, Centre Hospitalier Universitaire Vaudois, Universitiy of Lausanne, Switzerland
    • Bates, Matthew. University College London Medical School, Centre for Clinical Microbiology, University College London, United Kingdom
    • Schwank, Samana. University College London Medical School, Centre for Clinical Microbiology, University College London, United Kingdom
    • O'Grady, Justin. University College London Medical School, Centre for Clinical Microbiology, University College London, United Kingdom
    • Pletschette, Michel. Unit for Evaluation and Audit Directorate for Public Health, European Commission Brussels, Belgium
    • Ditui, Lucica. STOP TB Partnership, WHO
    • Atun, Rifat. The Global Fund, Chemin de Blandonnet 8, Geneva, Switzerland
    • Zumla, Alimuddin. University College London Medical School, Centre for Clinical Microbiology, University College London, United Kingdom
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 2012, vol. 205, p. S147-S158. Oxford University Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:297129
    Summary
    Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary tuberculosis in a timely fashion, allowing continued Mycobacterium tuberculosis transmission within communities. Currently recommended gold-standard diagnostic tests for tuberculosis are laboratory based, and multiple investigations may be necessary over a period of weeks or months before a diagnosis is made. Several new diagnostic tests have recently become available for detecting active tuberculosis disease, screening for latent M. tuberculosis infection, and identifying drug-resistant strains of M. tuberculosis. However, progress toward a robust point-of-care test has been limited, and novel biomarker discovery remains challenging. In the absence of effective prevention strategies, high rates of early case detection and subsequent cure are required for global tuberculosis control. Early case detection is dependent on test accuracy, accessibility, cost, and complexity, but also depends on the political will and funder investment to deliver optimal, sustainable care to those worst affected by the tuberculosis and human immunodeficiency virus epidemics. This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics