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Regulating cellular oxygen sensing by hydroxylation

Fandrey, Joachim

In: Cardiovascular Research, 2006, vol. 71, no. 4, p. 642-651

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    Titel
    • Regulating cellular oxygen sensing by hydroxylation
    Autor
    • Fandrey, Joachim
    Beteiligter
    • Gorr, Thomas A.. joint author
    • Gassmann, Max. joint author
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Cardiovascular Research, 2006, vol. 71, no. 4, p. 642-651. Elsevier Science
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:297060
    Summary
    Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation