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Microcrystals as DAMPs and their role in joint inflammation

Busso, Nathalie ; So, Alexander

In: Rheumatology, 2012, vol. 51, no. 7, p. 1154-1160

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    Titre
    • Microcrystals as DAMPs and their role in joint inflammation
    Auteur
    • Busso, Nathalie. Service de Rhumatologie, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
    • So, Alexander. Service de Rhumatologie, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297019
    Summary
    Microcrystals associated with joint diseases, namely monosodium urate, calcium pyrophosphate and basic calcium phosphate, can be considered as ‘danger signals' to the innate immune system and provoke inflammation through inflammasome-dependent as well as inflammasome-independent pathways. Direct crystal membrane interactions can also lead to cell activation. The result is the generation of IL-1β and other pro-inflammatory cytokines. The primacy of IL-1β in the case of gouty inflammation has been demonstrated by the efficacy of IL-1 inhibitors in clinical studies. These findings may be relevant to other diseases where crystal formation is found, such as OA and atherosclerosis