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Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

Kovari, Helen ; Sabin, Caroline A. ; Ledergerber, Bruno ; Ryom, Lene ; Worm, Signe W. ; Smith, Colette ; Phillips, Andrew ; Reiss, Peter ; Fontas, Eric ; Petoumenos, Kathy ; De Wit, Stéphane ; Morlat, Philippe ; Lundgren, Jens D. ; Weber, Rainer

In: Clinical Infectious Diseases, 2013, vol. 56, no. 6, p. 870-879

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    Titel
    • Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study
    Autor
    • Kovari, Helen. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Sabin, Caroline A.. Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College, London, United Kingdom
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Ryom, Lene. Copenhagen HIV Programme, University of Copenhagen, Denmark
    • Worm, Signe W.. Copenhagen HIV Programme, University of Copenhagen, Denmark
    • Smith, Colette. Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College, London, United Kingdom
    • Phillips, Andrew. Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College, London, United Kingdom
    • Reiss, Peter. HIV Monitoring Foundation, Academic Medical Center, Amsterdam, The Netherlands
    • Fontas, Eric. Département de Santé Publique, Centre Hospitalier Universitaire, Nice, France
    • Petoumenos, Kathy. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    • De Wit, Stéphane. Department of Infectious Diseases, St Pierre University Hospital, Brussels, Belgium
    • Morlat, Philippe. Service de Medicine Interne et Maladies Infectieuses, Hopital Saint-André, CHU de Bordeaux, France
    • Lundgren, Jens D.. Copenhagen HIV Programme, University of Copenhagen, Denmark
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Clinical Infectious Diseases, 2013, vol. 56, no. 6, p. 870-879. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:296384
    Summary
    In a large prospective multicohort study 22 910 human immunodeficiency virus-positive participants without hepatitis B or C virus coinfection were followed for 114 478 patient-years. The incidence of liver-related death was low at 0.10 per 1000 patient-years. Liverrelated mortality due to antiretroviral drug-related toxicity was rare