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Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity

Debbink, Kari ; Lindesmith, Lisa C. ; Donaldson, Eric F. ; Costantini, Veronica ; Beltramello, Martina ; Corti, Davide ; Swanstrom, Jesica ; Lanzavecchia, Antonio ; Vinjé, Jan ; Baric, Ralph S.

In: The Journal of Infectious Diseases, 2013, vol. 208, no. 11, p. 1877-1887

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    Titre
    • Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity
    Auteur
    • Debbink, Kari. Department of Microbiology and Immunology
    • Lindesmith, Lisa C.. Department of Epidemiology, University of North Carolina, Chapel Hill
    • Donaldson, Eric F.. Department of Epidemiology, University of North Carolina, Chapel Hill
    • Costantini, Veronica. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
    • Beltramello, Martina. Institute for Research in Biomedicine
    • Corti, Davide. Institute for Research in Biomedicine
    • Swanstrom, Jesica. Department of Epidemiology, University of North Carolina, Chapel Hill
    • Lanzavecchia, Antonio. Institute for Research in Biomedicine
    • Vinjé, Jan. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
    • Baric, Ralph S.. Department of Microbiology and Immunology
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2013, vol. 208, no. 11, p. 1877-1887. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:296371
    Summary
    Background. GII.4 noroviruses are a significant source of acute gastroenteritis worldwide, causing the majority of human norovirus outbreaks. Evolution of the GII.4 major capsid protein occurs rapidly, resulting in the emergence of new strains that produce successive waves of pandemic disease. A new pandemic isolate, GII.4 2012 Sydney, largely replaced previously circulating strains in late 2012. We compare the antigenic properties of GII.4 2012 Sydney with previously circulating strains. Methods. To determine whether GII.4-2012 Sydney is antigenically different from recently circulating strains GII.4-2006 Minerva and GII.4-2009 New Orleans in previously identified blockade epitopes, we compared reactivity and blockade profiles of GII.4-2006, GII.4-2009, and GII.4-2012 virus-like particles in surrogate neutralization/blockade assays using monoclonal antibodies and human polyclonal sera. Results. Using monoclonal antibodies that map to known blockade epitopes in GII.4-2006 and GII.4-2009 and human outbreak polyclonal sera, we demonstrate either complete loss or significantly reduced reactivity and blockade of GII.4.2012 compared to GII.4-2006 and GII.4-2009. Conclusions. GII.4-2012 Sydney is antigenically different from GII.4-2006 Minerva and GII.4-2009 New Orleans in at least 2 key blockade epitopes. Viral evolution in key potential neutralization epitopes likely allowed GII.4-2012 to escape from human herd immunity and emerge as the new predominant strain