Low Incidence of Community-Acquired Pneumonia among Human Immunodeficiency Virus-Infected Patients after Interruption of Pneumocystis carinii Pneumonia Prophylaxis

Eigenmann, Christina ; Flepp, Markus ; Bernasconi, Enos ; Schiffer, Veronique ; Telenti, Amalio ; Bucher, Heiner ; Wagels, Thomas ; Egger, Martin ; Furrer, Hansjakob

In: Clinical Infectious Diseases, 2003, vol. 36, no. 7, p. 917-921

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    Summary
    We compared the incidence of bacterial pneumonia among 336 patients who discontinued trimethoprim-sulfamethoxazole (TMP-SMX) as prophylaxis against Pneumocystis carinii pneumonia (PCP) with that among 75 patients who fulfilled the criteria for discontinuation but continued receiving prophylaxis. The difference in the overall incidence rates for the 2 groups (1.2 events per 100 person-years) was not statistically significant. Discontinuation of TMP-SMX prophylaxis against PCP is not associated with a significant increase in the incidence of bacterial pneumonia among patients with a sustained CD4 cell count increase to >200 cells/μL