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The IntAct molecular interaction database in 2012

Kerrien, Samuel ; Aranda, Bruno ; Breuza, Lionel ; Bridge, Alan ; Broackes-Carter, Fiona ; Chen, Carol ; Duesbury, Margaret ; Dumousseau, Marine ; Feuermann, Marc ; Hinz, Ursula ; Jandrasits, Christine ; Jimenez, Rafael C. ; Khadake, Jyoti ; Mahadevan, Usha ; Masson, Patrick ; Pedruzzi, Ivo ; Pfeiffenberger, Eric ; Porras, Pablo ; Raghunath, Arathi ; Roechert, Bernd ; Orchard, Sandra ; Hermjakob, Henning

In: Nucleic Acids Research, 2012, vol. 40, no. D1, p. D841-D846

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    Title
    • The IntAct molecular interaction database in 2012
    Author
    • Kerrien, Samuel. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Aranda, Bruno. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Breuza, Lionel. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Bridge, Alan. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Broackes-Carter, Fiona. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Chen, Carol. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Duesbury, Margaret. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Dumousseau, Marine. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Feuermann, Marc. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Hinz, Ursula. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Jandrasits, Christine. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Jimenez, Rafael C.. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Khadake, Jyoti. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Mahadevan, Usha. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Masson, Patrick. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Pedruzzi, Ivo. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Pfeiffenberger, Eric. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Porras, Pablo. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Raghunath, Arathi. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Roechert, Bernd. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Orchard, Sandra. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    • Hermjakob, Henning. EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, 1211-4 Geneva, Switzerland, Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z4 and Molecular Connections Private Limited, Basavanagudi, Bangalore 560 004, India
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Nucleic Acids Research, 2012, vol. 40, no. D1, p. D841-D846. Oxford University Press
    Other Version
    Classification
    • Health
    Keywords
    OAI-PMH Identifier
    • oai:doc.rero.ch:295677
    Summary
    IntAct is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. Two levels of curation are now available within the database, with both IMEx-level annotation and less detailed MIMIx-compatible entries currently supported. As from September 2011, IntAct contains approximately 275 000 curated binary interaction evidences from over 5000 publications. The IntAct website has been improved to enhance the search process and in particular the graphical display of the results. New data download formats are also available, which will facilitate the inclusion of IntAct's data in the Semantic Web. IntAct is an active contributor to the IMEx consortium (http://www.imexconsortium.org). IntAct source code and data are freely available at http://www.ebi.ac.uk/intact