Fulltext

Activity of minocycline against Toxoplasma gondii infection in mice

Chang, Hernan R. ; Comte, Raymonde ; Piguet, Pierre-François ; Pechère, Jean-Claude

In: Journal of Antimicrobial Chemotherapy, 1991, vol. 27, no. 5, p. 639-645

Ajouter à la liste personnelle
    Titre
    • Activity of minocycline against Toxoplasma gondii infection in mice
    Auteur
    • Chang, Hernan R.. Departments of Microbiology, University of Geneva Medical School C.M.U., 9 av. de Champel, 1211 Geneva 4, Switzerland
    • Comte, Raymonde. Departments of Microbiology, University of Geneva Medical School C.M.U., 9 av. de Champel, 1211 Geneva 4, Switzerland
    • Piguet, Pierre-François. Departments of Pathology, University of Geneva Medical School C.M.U., 9 av. de Champel, 1211 Geneva 4, Switzerland
    • Pechère, Jean-Claude. Departments of Microbiology, University of Geneva Medical School C.M.U., 9 av. de Champel, 1211 Geneva 4, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1991, vol. 27, no. 5, p. 639-645. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295207
    Summary
    The chemotherapeutic activity of minocycline, a semi-synthetic tetracycline analogue, was evaluated in a murine model of toxoplasmosis. A lethal acute toxoplas-mosis was produced by injecting 105 tachyzoites of the RH strain of Toxoplasma gondii into the peritoneal cavities of Swiss-Webster mice. When infected mice were treated once daily for 12 days, starting 2 h after challenge, the survival and cure rates were 100% and 40% respectively after minocycline alone (100 mg/kg per day), 0% and 0% after pyrimethamine alone (8.5 mg/kg per day), and 100% and 50% after combination of the two drugs at the same dosages. Absolute survival and cure with minocycline were observed when mice were treated with two daily doses of 100 mg/kg for 12 days. Mice chronically infected with a low virulent strain of T. gondii (Me49) showed a significant reduction in the number of brain cysts after three weeks of treatment with 50 mg/kg per day of minocycline. Minocycline serum levels after a single oral administration of 50 mg/kg or 100 mg/kg to normal mice, peaked at 1.8 mg/1 and 10 mg/1 after 1 h, respectively, and showed an extended half-life