Assessment of varicella vaccine effectiveness in Germany: a time-series approach

HÖHLE, M. ; SIEDLER, A. ; BADER, H.-M ; LUDWIG, M. ; HEININGER, U. ; VON KRIES, R.

In: Epidemiology and Infection, 2011, vol. 139, no. 11, p. 1710-1719

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    Summary
    A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA