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Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study

Räber, Lorenz ; Taniwaki, Masanori ; Zaugg, Serge ; Kelbæk, Henning ; Roffi, Marco ; Holmvang, Lene ; Noble, Stephane ; Pedrazzini, Giovanni ; Moschovitis, Aris ; Lüscher, Thomas F. ; Matter, Christian M. ; Serruys, Patrick W. ; Jüni, Peter ; Garcia-Garcia, Hector M. ; Windecker, Stephan

In: European Heart Journal, 2015, vol. 36, no. 8, p. 490-500

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    Titel
    • Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study
    Autor
    • Räber, Lorenz. Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland
    • Taniwaki, Masanori. Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland
    • Zaugg, Serge. Clinical Trials Unit, Bern University, Bern, Switzerland
    • Kelbæk, Henning. Cardiac Catheterization Laboratory, Rigshospitalet, Copenhagen, Denmark
    • Roffi, Marco. Division of Cardiology, University Hospital, Geneva, Switzerland
    • Holmvang, Lene. Cardiac Catheterization Laboratory, Rigshospitalet, Copenhagen, Denmark
    • Noble, Stephane. Division of Cardiology, University Hospital, Geneva, Switzerland
    • Pedrazzini, Giovanni. Cardiocentro, Lugano, Switzerland
    • Moschovitis, Aris. Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland
    • Lüscher, Thomas F.. Cardiology Department, University Hospital Zurich, Zurich, Switzerland
    • Matter, Christian M.. Cardiology Department, University Hospital Zurich, Zurich, Switzerland
    • Serruys, Patrick W.. Cardialysis BV, Rotterdam, The Netherlands
    • Jüni, Peter. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    • Garcia-Garcia, Hector M.. Cardialysis BV, Rotterdam, The Netherlands
    • Windecker, Stephan. Department of Cardiology, Bern University Hospital, 3010, Bern, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • European Heart Journal, 2015, vol. 36, no. 8, p. 490-500. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:294207
    Summary
    Aim The effect of long-term high-intensity statin therapy on coronary atherosclerosis among patients with acute ST-segment elevation myocardial infarction (STEMI) is unknown. The aim of this study was to quantify the impact of high-intensity statin therapy on plaque burden, composition, and phenotype in non-infarct-related arteries of STEMI patients undergoing primary percutaneous coronary intervention (PCI). Methods and results Between September 2009 and January 2011, 103 STEMI patients underwent intravascular ultrasonography (IVUS) and radiofrequency ultrasonography (RF-IVUS) of the two non-infarct-related epicardial coronary arteries (non-IRA) after successful primary PCI. Patients were treated with high-intensity rosuvastatin (40 mg/day) throughout 13 months and serial intracoronary imaging with the analysis of matched segments was available for 82 patients with 146 non-IRA. The primary IVUS end-point was the change in per cent atheroma volume (PAV). After 13 months, low-density lipoprotein cholesterol (LDL-C) had decreased from a median of 3.29 to 1.89 mmol/L (P < 0.001), and high-density lipoprotein cholesterol (HDL-C) levels had increased from 1.10 to 1.20 mmol/L (P < 0.001). PAV of the non-IRA decreased by −0.9% (95% CI: −1.56 to −0.25, P = 0.007). Patients with regression in at least one non-IRA were more common (74%) than those without (26%). Per cent necrotic core remained unchanged (−0.05%, 95% CI: −1.05 to 0.96%, P = 0.93) as did the number of RF-IVUS defined thin cap fibroatheromas (124 vs. 116, P = 0.15). Conclusion High-intensity rosuvastatin therapy over 13 months is associated with regression of coronary atherosclerosis in non-infarct-related arteries without changes in RF-IVUS defined necrotic core or plaque phenotype among STEMI patients