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Monitoring Responses to Antiretroviral Treatment in Human Immunodeficiency Virus Type 1 (HIV-l)—Infected Patients by Serial Lymph Node Aspiration

Bürgisser, Philippe ; Spertini, François ; Weyrich-Suter, Catherine ; Pagani, Jean-Luc ; Meylan, Pascal R. A.

In: Journal of Infectious Diseases, 1997, vol. 175, no. 5, p. 1202-1205

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    Titel
    • Monitoring Responses to Antiretroviral Treatment in Human Immunodeficiency Virus Type 1 (HIV-l)—Infected Patients by Serial Lymph Node Aspiration
    Autor
    • Bürgisser, Philippe. Division of Immunology and Allergy, Division of Infectious Diseases, and Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Spertini, François. Division of Immunology and Allergy, Division of Infectious Diseases, and Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Weyrich-Suter, Catherine. Division of Immunology and Allergy, Division of Infectious Diseases, and Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Pagani, Jean-Luc. Division of Immunology and Allergy, Division of Infectious Diseases, and Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Meylan, Pascal R. A.. Division of Immunology and Allergy, Division of Infectious Diseases, and Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of Infectious Diseases, 1997, vol. 175, no. 5, p. 1202-1205. The University of Chicago Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:294089
    Summary
    Fine-needle aspiration was used to collect lymph node cells (LNC) from 9 antiretroviral-naive patients entering a double-blind single- or combined-drug study of zidovudine, zalcitabine, and saquinavir. LNC were obtained twice before and 1 and 6 months after initiation of treatment. The effect of antiretroviral treatment on virus load ranged from no response to a dramatic decrease in plasma and LNC human immunodeficiency virus (HIV) RNA levels. The decrease in unspliced or spliced (or both) HIV RNAs in LNC was correlated with but consistently smaller than the decrease in plasma viremia. When present, the increase in blood CD4 T cells was, in general, moderate and transient. However, a striking rise in blood CD4 T cell count and in LNC CD4:CD8 ratio was observed in the 1 patient with the deepest sustained decrease in HIV RNA level in both plasma and lymph nodes