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Monographies on drugs, which are frequently analysed in the course of Therapeutic Drug Monitoring Monographien über Medikamente, die regelmässig im Rahmen des Therapeutic Drug Monitorings analysiert werden

Rentsch, K. ; Fathi, M. ; Grignaschi, N. ; Magnin, J.L. ; Printzen, G. ; Thormann, W. ; Wenk, M. ; Werner, D.

In: LaboratoriumsMedizin, 2005, vol. 29, no. 4, p. 287-297

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    Title
    • Monographies on drugs, which are frequently analysed in the course of Therapeutic Drug Monitoring Monographien über Medikamente, die regelmässig im Rahmen des Therapeutic Drug Monitorings analysiert werden
    Author
    • Rentsch, K.. Chair person, UniversitätsSpital Zürich
    • Fathi, M.. Universitätsspital Genf
    • Grignaschi, N.. Universitätsspital Basel
    • Magnin, J.L.. Kantonsspital Freiburg
    • Printzen, G.. Inselspital Bern
    • Thormann, W.. Universität Bern
    • Wenk, M.. Universitätsspital Basel
    • Werner, D.. Universitätsspital Lausanne
    Document Type
    • Postprint
    Language
    • Multiple languages
    Published in
    • LaboratoriumsMedizin, 2005, vol. 29, no. 4, p. 287-297. Walter de Gruyter
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:294072
    Summary
    In 1995 the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) has already published a printed version of drug monographs, which are now newly compiled and presented in a standardised manner. The aim of these monographs is to give an overview on the most important informations that are necessary in order to request a drug analysis or is helpful to interpret the results. Therefore, the targeted audience are laboratory health professionals or the receivers of the reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half life time and elimination routes as well as information on therapeutic or toxic concentrations. Because preanalytical considerations are of particular importance for therapeutic drug monitoring, there is also information given at which time the determination of the drug concentration is reasonable and when steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s), respectively, after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for you handling therapeutic drug monitoring and look forward to comments of the audience