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Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy

Lindau, Nicolas T. ; Bänninger, Balthasar J. ; Gullo, Miriam ; Good, Nicolas A. ; Bachmann, Lukas C. ; Starkey, Michelle L. ; Schwab, Martin E.

In: Brain, 2014, vol. 137, no. 3, p. 739-756

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    Titel
    • Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy
    Autor
    • Lindau, Nicolas T.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Bänninger, Balthasar J.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Gullo, Miriam. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Good, Nicolas A.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Bachmann, Lukas C.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Starkey, Michelle L.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    • Schwab, Martin E.. Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Brain, 2014, vol. 137, no. 3, p. 739-756. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:294038
    Summary
    The adult CNS has limited potential for functional recovery after structural lesions. Lindau et al. report that a blocking antibody to the neurite-growth inhibitory protein Nogo-A improved functional recovery in a rat sensorimotor cortex stroke model. The functional recovery was accompanied by increased corticospinal innervation from the contralateral cortex