Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy

Lindau, Nicolas T. ; Bänninger, Balthasar J. ; Gullo, Miriam ; Good, Nicolas A. ; Bachmann, Lukas C. ; Starkey, Michelle L. ; Schwab, Martin E.

In: Brain, 2014, vol. 137, no. 3, p. 739-756

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    The adult CNS has limited potential for functional recovery after structural lesions. Lindau et al. report that a blocking antibody to the neurite-growth inhibitory protein Nogo-A improved functional recovery in a rat sensorimotor cortex stroke model. The functional recovery was accompanied by increased corticospinal innervation from the contralateral cortex