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Dietary folates and cancer risk in a network of case-control studies

Tavani, A. ; Malerba, S. ; Pelucchi, C. ; Dal Maso, L. ; Zucchetto, A. ; Serraino, D. ; Levi, F. ; Montella, M. ; Franceschi, S. ; Zambon, A. ; La Vecchia, C.

In: Annals of Oncology, 2012, vol. 23, no. 10, p. 2737-2742

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    Titre
    • Dietary folates and cancer risk in a network of case-control studies
    Auteur
    • Tavani, A.. Department of Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Malerba, S.. Department of Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Pelucchi, C.. Department of Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Dal Maso, L.. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy
    • Zucchetto, A.. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy
    • Serraino, D.. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy
    • Levi, F.. Cancer Epidemiology Unit and Registre Vaudois des Tumeurs, Institut universitaire de médecine sociale et préventive, Lausanne, Switzerland
    • Montella, M.. Unit of Epidemiology, Istituto Tumori ‘Fondazione Pascale', Naples, Italy
    • Franceschi, S.. International Agency for Research on Cancer, Lyon, France
    • Zambon, A.. Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano-Bicocca, Milan
    • La Vecchia, C.. Department of Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 2012, vol. 23, no. 10, p. 2737-2742. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294004
    Summary
    Background Folate deficiency leads to DNA damage and inadequate repair, caused by a decreased synthesis of thymidylate and purines. We analyzed the relationship between dietary folate intake and the risk of several cancers. Patients and methods The study is based on a network of case-control studies conducted in Italy and Switzerland in 1991-2009. The odds ratios (ORs) for dietary folate intake were estimated by multiple logistic regression models, adjusted for major identified confounding factors. Results For a few cancer sites, we found a significant inverse relation, with ORs for an increment of 100μg/day of dietary folate of 0.65 for oropharyngeal (1467 cases), 0.58 for esophageal (505 cases), 0.83 for colorectal (2390 cases), 0.72 for pancreatic (326 cases), 0.67 for laryngeal (851 cases) and 0.87 for breast (3034 cases) cancers. The risk estimates were below unity, although not significantly, for cancers of the endometrium (OR=0.87, 454 cases), ovary (OR=0.86, 1031 cases), prostate (OR=0.91, 1468 cases) and kidney (OR=0.88, 767 cases), and was 1.00 for stomach cancer (230 cases). No material heterogeneity was found in strata of sex, age, smoking and alcohol drinking. Conclusions Our data support a real inverse association of dietary folate intake with the risk of several common cancers