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A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings

Pries, Axel R. ; Habazettl, Helmut ; Ambrosio, Giuseppe ; Hansen, Peter Riis ; Kaski, Juan Carlos ; Schächinger, Volker ; Tillmanns, Harald ; Vassalli, Giuseppe ; Tritto, Isabella ; Weis, Michael ; de Wit, Cor ; Bugiardini, Raffaele

In: Cardiovascular Research, 2008, vol. 80, no. 2, p. 165-174

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    Titre
    • A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings
    Auteur
    • Pries, Axel R.. Department of Physiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, D-14195 Berlin, Germany
    • Habazettl, Helmut. Department of Physiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, D-14195 Berlin, Germany
    • Ambrosio, Giuseppe. Division of Cardiology, University of Perugia School of Medicine, Ospedale Silvestrini, 06156 Perugia, Italy
    • Hansen, Peter Riis. Department of Cardiology P, Kas Gentofte, 2900 Hellerup, Denmark
    • Kaski, Juan Carlos. Cardiac and Vascular Sciences, St George's, University of London, London SW17 0RE, UK
    • Schächinger, Volker. Med. Klinik IV, JWG-Universität Frankfurt, 60590 Frankfurt, Germany
    • Tillmanns, Harald. Abt. Innere Medizin, Zentrum für Innere Medizin, Gießen, Germany
    • Vassalli, Giuseppe. Division de Cardiologie, CHUV, 1011 Lausanne, Switzerland
    • Tritto, Isabella. Division of Cardiology, University of Perugia School of Medicine, Ospedale Silvestrini, 06156 Perugia, Italy
    • Weis, Michael. Med. Klinik u. Poliklinik I, LMU München, Klinikum Großhadern, Munich, Germany
    • de Wit, Cor. Institut für Physiologie, Universität zu Lübeck, Lübeck, Germany
    • Bugiardini, Raffaele. Dipartimento di Medicina Interna, Policlinico S. Orsola, 40138 Bologna, Italy
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cardiovascular Research, 2008, vol. 80, no. 2, p. 165-174. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293743
    Summary
    Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage—in the presence or absence of obstructive coronary atherosclerosis—will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options