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Hippocampal volume and declarative memory function in combat-related PTSD

WOODWARD, STEVEN H. ; KALOUPEK, DANNY G. ; GRANDE, LAURA J. ; STEGMAN, WENDY K. ; KUTTER, CATHERINE J. ; LESKIN, LORAINE ; PRESTEL, REBECCA ; SCHAER, MARIE ; REISS, ALLAN L. ; ELIEZ, STEPHAN

In: Journal of the International Neuropsychological Society, 2009, vol. 15, no. 6, p. 830-839

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    Title
    • Hippocampal volume and declarative memory function in combat-related PTSD
    Author
    • WOODWARD, STEVEN H.. Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Palo Alto, California
    • KALOUPEK, DANNY G.. Behavioral Science Division, National Center for PTSD, VA New England Health Care System, Boston, Massachusetts
    • GRANDE, LAURA J.. Psychology Service, VA New England Health Care System, Boston, Massachusetts
    • STEGMAN, WENDY K.. Earth Systems, Melbourne, Australia
    • KUTTER, CATHERINE J.. Psychology Service, White River Junction Veterans Affairs Medical Center, White River Junction, Vermont
    • LESKIN, LORAINE. Psychology Service, VA Greater Los Angeles Health Care System, Los Angeles, California
    • PRESTEL, REBECCA. Behavioral Science Division, National Center for PTSD, VA New England Health Care System, Boston, Massachusetts
    • SCHAER, MARIE. Department of Psychiatry, University of Geneva, Geneva, Switzerland
    • REISS, ALLAN L.. Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California
    • ELIEZ, STEPHAN. Department of Psychiatry, University of Geneva, Geneva, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of the International Neuropsychological Society, 2009, vol. 15, no. 6, p. 830-839. Cambridge University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:293397
    Summary
    The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed. (JINS, 2009, 15, 830-839.)