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Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection

Kouyos, Roger D. ; von Wyl, Viktor ; Yerly, Sabine ; Böni, Jürg ; Rieder, Philip ; Joos, Beda ; Taffé, Patrick ; Shah, Cyril ; Bürgisser, Philippe ; Klimkait, Thomas ; Weber, Rainer ; Hirschel, Bernard ; Cavassini, Matthias ; Rauch, Andri ; Battegay, Manuel ; Vernazza, Pietro L. ; Bernasconi, Enos ; Ledergerber, Bruno ; Bonhoeffer, Sebastian ; Günthard, Huldrych F.

In: Clinical Infectious Diseases, 2011, vol. 52, no. 4, p. 532-539

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    Titre
    • Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection
    Auteur
    • Kouyos, Roger D.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • von Wyl, Viktor. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Yerly, Sabine. Laboratory of Virology, University Hospital Geneva and University of Geneva Medical School
    • Böni, Jürg. Swiss National Center for Retroviruses, University of Zurich
    • Rieder, Philip. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Joos, Beda. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Taffé, Patrick. Swiss HIV Cohort Study Data Center
    • Shah, Cyril. Swiss National Center for Retroviruses, University of Zurich
    • Bürgisser, Philippe. Division of Immunology, University Hospital Lausanne, Lausanne
    • Klimkait, Thomas. Institute for Medical Microbiology, University of Basel
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Hirschel, Bernard. Division of Infectious Diseases, Geneva University Hospital, Geneva
    • Cavassini, Matthias. Division of Immunology, University Hospital Lausanne, Lausanne
    • Rauch, Andri. Clinic for Infectious Diseases, Bern University Hospital and University of Bern
    • Battegay, Manuel. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel
    • Vernazza, Pietro L.. Division of Infectious Diseases, Cantonal Hospital St Gallen, St Gallen
    • Bernasconi, Enos. Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Bonhoeffer, Sebastian. Institute of Integrative Biology, Eidgenössische Technische Hochschule Zurich, Zurich
    • Günthard, Huldrych F.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Clinical Infectious Diseases, 2011, vol. 52, no. 4, p. 532-539. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Mots clés
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293269
    Summary
    The fraction of ambiguous nucleotide calls in bulk sequencing of human immunodeficiency virus type 1 (HIV-1) carries important information on viral diversity and the age of infection. In particular, a fraction of ambiguous nucleotides of >.5% provides evidence against a recent infection event <1 year ago