Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection

Kouyos, Roger D. ; von Wyl, Viktor ; Yerly, Sabine ; Böni, Jürg ; Rieder, Philip ; Joos, Beda ; Taffé, Patrick ; Shah, Cyril ; Bürgisser, Philippe ; Klimkait, Thomas ; Weber, Rainer ; Hirschel, Bernard ; Cavassini, Matthias ; Rauch, Andri ; Battegay, Manuel ; Vernazza, Pietro L. ; Bernasconi, Enos ; Ledergerber, Bruno ; Bonhoeffer, Sebastian ; Günthard, Huldrych F.

In: Clinical Infectious Diseases, 2011, vol. 52, no. 4, p. 532-539

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    The fraction of ambiguous nucleotide calls in bulk sequencing of human immunodeficiency virus type 1 (HIV-1) carries important information on viral diversity and the age of infection. In particular, a fraction of ambiguous nucleotides of >.5% provides evidence against a recent infection event <1 year ago