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Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging

Bianda, Nicola ; Di Valentino, Marcello ; Périat, Daniel ; Segatto, Jeanne Marie ; Oberson, Michel ; Moccetti, Marco ; Sudano, Isabella ; Santini, Paolo ; Limoni, Costanzo ; Froio, Alberto ; Stuber, Matthias ; Corti, Roberto ; Gallino, Augusto ; Wyttenbach, Rolf

In: European Heart Journal, 2012, vol. 33, no. 2, p. 230-237

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    Titre
    • Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging
    Auteur
    • Bianda, Nicola. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Di Valentino, Marcello. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Périat, Daniel. Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland
    • Segatto, Jeanne Marie. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Oberson, Michel. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Moccetti, Marco. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Sudano, Isabella. Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland
    • Santini, Paolo. Department of Radiology, Ospedale San Giovanni, Bellinzona, Switzerland
    • Limoni, Costanzo. University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland
    • Froio, Alberto. Department of Vascular Surgery, Ospedale San Gerardo, Monza, Italy
    • Stuber, Matthias. Center of Bio Medical Imaging, University Hospital, Lausanne, Switzerland
    • Corti, Roberto. Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland
    • Gallino, Augusto. Division of Cardiology and Vascular Medicine, Department of Internal Medicine, Ospedale San Giovanni, 6500 Bellinzona, Switzerland
    • Wyttenbach, Rolf. Department of Radiology, Ospedale San Giovanni, Bellinzona, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Heart Journal, 2012, vol. 33, no. 2, p. 230-237. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293261
    Summary
    Aims The time course of atherosclerosis burden in distinct vascular territories remains poorly understood. We longitudinally evaluated the natural history of atherosclerotic progression in two different arterial territories using high spatial resolution magnetic resonance imaging (HR-MRI), a powerful, safe, and non-invasive tool. Methods and results We prospectively studied a cohort of 30 patients (mean age 68.3, n = 9 females) with high Framingham general cardiovascular disease 10-year risk score (29.5%) and standard medical therapy with mild-to-moderate atherosclerosis intra-individually at the level of both carotid and femoral arteries. A total of 178 HR-MRI studies of carotid and femoral arteries performed at baseline and at 1- and 2-year follow-up were evaluated in consensus reading by two experienced readers for lumen area (LA), total vessel area (TVA), vessel wall area (VWA = TVA − LA), and normalized wall area index (NWI = VWA/TVA). At the carotid level, LA decreased (−3.19%/year, P = 0.018), VWA increased (+3.83%/year, P = 0.019), and TVA remained unchanged. At the femoral level, LA remained unchanged, VWA and TVA increased (+5.23%/year and +3.11%/year, both P < 0.01), and NWI increased for both carotid and femoral arteries (+2.28%/year, P = 0.01, and +1.8%/year, P = 0.033). Conclusion The atherosclerotic burden increased significantly in both carotid and femoral arteries. However, carotid plaque progression was associated with negative remodelling, whereas the increase in femoral plaque burden was compensated by positive remodelling. This finding could be related to anatomic and flow differences and/or to the distinct degree of obstruction in the two arterial territories