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A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women

Conen, David ; Ridker, Paul M. ; Everett, Brendan M. ; Tedrow, Usha B. ; Rose, Lynda ; Cook, Nancy R. ; Buring, Julie E. ; Albert, Christine M.

In: European Heart Journal, 2010, vol. 31, no. 14, p. 1730-1736

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    Titre
    • A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women
    Auteur
    • Conen, David. Center for Arrhythmia Prevention Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Ridker, Paul M.. Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Everett, Brendan M.. Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Tedrow, Usha B.. Center for Arrhythmia Prevention Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Rose, Lynda. Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Cook, Nancy R.. Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Buring, Julie E.. Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    • Albert, Christine M.. Center for Arrhythmia Prevention Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Heart Journal, 2010, vol. 31, no. 14, p. 1730-1736. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:292733
    Summary
    Aims To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women. Methods and results We performed a prospective cohort study among women participating in the Women's Health Study. All women were free of AF at study entry and provided a baseline blood sample assayed for high-sensitivity C-reactive protein, soluble intercellular adhesion molecule-1, and fibrinogen. To evaluate the joint effect of these three biomarkers, an inflammation score was created that ranged from 0 to 3 and reflected the number of biomarkers in the highest tertile per individual. During a median follow-up of 14.4 years, 747 of 24 734 women (3.0%) experienced a first AF event. Assessed individually, all three biomarkers were associated with incident AF, even after adjustment for traditional risk factors. When combined into an inflammation score, a strong and independent relationship between inflammation and incident AF emerged. Across increasing inflammation score categories, there were 1.66, 2.22, 2.73, and 3.25 AF events per 1000 person-years of follow-up. The corresponding hazard ratios (95% confidence intervals) across inflammation score categories were 1.0, 1.22 (1.00-1.49), 1.32 (1.06-1.65), and 1.59 (1.22-2.06) (P for linear trend 0.0006) after multivariable adjustment. Conclusion In this large-scale prospective study among women without a history of cardiovascular disease, markers of systemic inflammation were significantly related to AF even after controlling for traditional risk factors