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Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village

Babiker, H. A. ; Charlwood, J. D. ; Smith, T. ; Walliker, D.

In: Parasitology, 1995, vol. 111, no. 4, p. 433-442

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    Titre
    • Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village
    Auteur
    • Babiker, H. A.. Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    • Charlwood, J. D.. National Institute for Medical Research, Ifakara Centre, P.O. Box 53, Ifakara, Tanzania
    • Smith, T.. Department of Public Health and Epidemiology, Swiss Tropical Institute, Postfach, CH-4002, Basel, Switzerland
    • Walliker, D.. Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:292269
    Summary
    The diversity of the genes encoding 2 merozoite surface proteins (MSP-1 and MSP-2) of Plasmodium falciparum has been examined in parasites infecting members of 4 households in a village in Tanzania. The polymerase chain reaction (PCR) was used to characterize allelic variants of these genes by the sizes and sequences of regions of tandemly repeated bases in each gene. In each household extensive polymorphism was detected among parasites in the inhabitants and in infected mosquitoes caught in their houses. Similar frequencies of the alleles of these genes were observed in all households. Capture-recapture data indicated that both Anopheles gambiae and A.funestus freely dispersed among households in the hamlet. The results confirm that cross-mating and gene flow occur extensively among the parasites, and are discussed within the context of spatial clustering of natural populations of P. falciparum