Fulltext

Penetration of rifampicin into the brain tissue and cerebral extracellular space of rats

Mindermann, Thomas ; Landolt, Hans ; Zimmerli, Werner ; Rajacic, Zarko ; Gratzl, Otmar

In: Journal of Antimicrobial Chemotherapy, 1993, vol. 31, no. 5, p. 731-737

Ajouter à la liste personnelle
    Titre
    • Penetration of rifampicin into the brain tissue and cerebral extracellular space of rats
    Auteur
    • Mindermann, Thomas. Neurosurgical University Clinics 4031 Basle, Switzerland
    • Landolt, Hans. Neurosurgical University Clinics 4031 Basle, Switzerland
    • Zimmerli, Werner. Division of Infectious Diseases and Department of Research and Internal Medicine, University Hospitals Basle 4031 Basle, Switzerland
    • Rajacic, Zarko. Division of Infectious Diseases and Department of Research and Internal Medicine, University Hospitals Basle 4031 Basle, Switzerland
    • Gratzl, Otmar. Neurosurgical University Clinics 4031 Basle, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1993, vol. 31, no. 5, p. 731-737. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:292183
    Summary
    Rifampicin is used to treat neurosurgical shunt infections because of its excellent in-vitro activity against staphylococci and its adequate penetration into the CSF. However, nothing is known about rifampicin concentrations in the cerebral extracellular space (CES). We measured the penetration of rifampicin into the CES of anaesthetized rats by microdialysis using low-flow and equilibrium methods. Depending on the method, rifampicin concentrations in the CES were 0·3-1% of the serum concentration or 3-8% of brain tissue concentration, respectively. These experimental data in animals suggest that the recommended dose of rifampicin in man might be inadequate for treatment of some brain infections