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Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions

Wick, Peter ; Grafmueller, Stefanie ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: MRS Bulletin, 2014, vol. 39, no. 11, p. 984-989

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    Titre
    • Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions
    Auteur
    • Wick, Peter. Empa, Swiss Federal Laboratories for Materials Science and Technology, Switzerland; peter.wick@empa.ch
    • Grafmueller, Stefanie. Empa, Swiss Federal Laboratories for Materials Science and Technology, Switzerland; stefanie.grafmueller@empa.ch
    • Petri-Fink, Alke. Adolphe Merkle Institute, University of Fribourg, Switzerland; alke.fink@unifr.ch
    • Rothen-Rutishauser, Barbara. Adolphe Merkle Institute, University of Fribourg, Switzerland; barbara.rothen@unifr.ch
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • MRS Bulletin, 2014, vol. 39, no. 11, p. 984-989. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291820
    Summary
    Engineered nanoparticles, in particular metal oxide nanoparticles, with their unique and novel properties, enable a plethora of new applications in various fields of research. These new properties have raised concerns about potential adverse effects for the environment and human health and are nowadays very controversial. A reliable, cost- and time-effective, rapid and mechanistic-based testing strategy is needed to replace current conventional phenomenological assessments. Today's in vitro technology, providing human-based advanced cellular models representing different organ barriers such as skin, lung, placenta, or liver, may cover this need. The aim of this article is to present the current changes in (nano) toxicology strategies, the extent to which in vitro models have achieved general acceptance, and how the relevance of these models can further be improved using examples of selected metal oxide nanoparticles