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Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases

Kinloch-de Loës, Sabine ; de Saussure, Philippe ; Saurat, Jean-Hilaire ; Stalder, Hans ; Hirschel, Bernard ; Perrin, Luc H.

In: Clinical Infectious Diseases, 1993, vol. 17, no. 1, p. 59-65

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    Title
    • Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases
    Author
    • Kinloch-de Loës, Sabine. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    • de Saussure, Philippe. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    • Saurat, Jean-Hilaire. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    • Stalder, Hans. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    • Hirschel, Bernard. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    • Perrin, Luc H.. Central Laboratory of Virology, Department of Dermatology, Policlinic of Medicine, and Division of Infectious Diseases, Department of Medicine, University Cantonal Hospital, Geneva, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 1993, vol. 17, no. 1, p. 59-65. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:291582
    Summary
    In this series of 31 patients with acute infection due to human immunodeficiency virus (HIV) type 1, the male-to-female ratio was 3.4:1 and the mean age was 31.3 years. Sexual transmission accounted for 83.9% of cases; 45.2% of the patients were homosexual and 38.7% were heterosexual. The mean duration of symptoms and signs was 21 days (range, 5-60 days). Fever (87.1%) and skin rash (67.7%) were most commonly reported. Physical examination findings were abnormal for 96% of the patients; the oral cavity (76.7%) and the skin (73.3%) were the most frequently involved sites. Thirteen of 25 patients with sexually acquired infection had genital or oral ulcers, whereas five intravenous drug users had none (P = .052). Thrombocytopenia was the most common hematologic abnormality and was detected in 17 of 23 patients tested. P24 antigenemia, an initially negative screening test for HIV antibody, and a low CD4+ lymphocyte count were noted in 23 of 29, 23 of 30, and 14 of 21 tested patients, respectively