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Effect of individual- and group-level antibiotic exposure on MRSA isolation: a multilevel analysis

Muller, Arno ; Mauny, Frédéric ; Talon, Daniel ; Donnan, Peter T. ; Harbarth, Stephan ; Bertrand, Xavier

In: Journal of Antimicrobial Chemotherapy, 2006, vol. 58, no. 4, p. 878-881

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    Title
    • Effect of individual- and group-level antibiotic exposure on MRSA isolation: a multilevel analysis
    Author
    • Muller, Arno. Service d'Hygiène hospitalière et d'Epidémiologie moléculaire, Centre Hospitalier Universitaire Jean Minjoz 25030 Besançon, France
    • Mauny, Frédéric. Département d'information médicale, Centre Hospitalier Universitaire Jean Minjoz Besançon, France
    • Talon, Daniel. Service d'Hygiène hospitalière et d'Epidémiologie moléculaire, Centre Hospitalier Universitaire Jean Minjoz 25030 Besançon, France
    • Donnan, Peter T.. Tayside Centre for General Practice, University of Dundee UK
    • Harbarth, Stephan. Service de Prévention et Contrôle de l'Infection Hôpitaux Universitaires de Genève, Switzerland
    • Bertrand, Xavier. Service d'Hygiène hospitalière et d'Epidémiologie moléculaire, Centre Hospitalier Universitaire Jean Minjoz 25030 Besançon, France
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Antimicrobial Chemotherapy, 2006, vol. 58, no. 4, p. 878-881. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:291034
    Summary
    Objectives: To observe the relative role of individual and group-level antimicrobial selective pressure on subsequent methicillin-resistant Staphylococcus aureus (MRSA) isolation in a university hospital. Methods: For this purpose, 18 596 patients were included in a retrospective statistical analysis, applying multilevel modelling with discrete time intervals at the lowest level. Individual-level and hospital group variables on antimicrobial exposure and MRSA colonization pressure were collected from computerized databases. Results: The simultaneous hospital group- and individual-level analysis showed individual exposure to fluoroquinolones and collective exposure to penicillins to be associated with MRSA isolation after adjustment for colonization pressure and other potential confounders. Conclusions: These results support efforts to reduce prescriptions of selected antimicrobial drug classes such as fluoroquinolones and show the added value of multilevel analysis for research on the adverse outcomes of antibiotic prescribing