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Diuretics and Vitamin B,: Are Diuretics a Risk Factor for Thiamin Malnutrition?

Suter, Paolo M. ; Vetter, Wilhelm

In: Nutrition Reviews, 2000, vol. 58, no. 10, p. 319-323

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    Titre
    • Diuretics and Vitamin B,: Are Diuretics a Risk Factor for Thiamin Malnutrition?
    Auteur
    • Suter, Paolo M.. Medical Policlinic, University Hospital, 8091 Zurich, Switzerland
    • Vetter, Wilhelm. Medical Policlinic, University Hospital, 8091 Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291000
    Summary
    Despite modern pharmacologic agents in the therapy of heart failure, the prevalence of heart failure is increasing worldwide. In the vitamin B1 deficiency disease beriberi, cardiac symptoms may represent the central feature. Two new studies confirmed that all diuretics lead to increased uri- nary thiamin excretion depending on the urinary flow rate. In a subject at risk, such as an elderly patient, chronic diuretic treatment may lead to a subclinical thiamin deficiency. Whether subclinical thiamin nutriture is a modulator of the prevalence andlor severity of heart failure is not known; however, it seems to be plausible from the metabolic point of view