Faculté des sciences

Anticancer activity of osmium metalla-rectangles

Barry, Nicolas P.E. ; Edafe , Fabio ; Dyson, Paul J. ; Therrien, Bruno

In: Dalton Transactions, 2010, vol. 39, no. 11, p. 2816-2820

A series of cationic metalla-rectangles of the general formula [(p-cymene)4Os4(OO∩OO)2(N∩N)2]4+ have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)2Os2 (OO∩OO)2Cl2] (OO∩OO =... More

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    Summary
    A series of cationic metalla-rectangles of the general formula [(p-cymene)4Os4(OO∩OO)2(NN)2]4+ have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)2Os2 (OO∩OO)2Cl2] (OO∩OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (NN = 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF3SO3. All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)4Os4(dhbq)2(4,4′-bipyridine)2]4+, shows an IC50 value of 5.7 μM (comparable to cisplatin) against A2780 cancer cells and 7.5 μM against the cisplatin resistant A2780cisR cells.