000029029 001__ 29029 000029029 005__ 20150420164349.0 000029029 0248_ $$aoai:doc.rero.ch:20120427081609-JA$$punifr$$ppostprint$$prero_explore$$particle$$zthesis_urn$$zreport$$zthesis$$zbook$$zcdu54$$zjournal$$zcdu16$$zpreprint$$zcdu1$$zdissertation$$zcdu34 000029029 041__ $$aeng 000029029 080__ $$a54 000029029 100__ $$aSpoden, Gilles A.$$uDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 245__ $$9eng$$aPolyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection 000029029 269__ $$c2011-10-03 000029029 520__ $$9eng$$aPolyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine concentrations required for inhibition of human papillomavirus and cytomegalovirus did not cause any cytotoxic effects. Polyethylenimines and their derivatives may thus be attractive molecules for the development of antiviral microbicides. 000029029 700__ $$aBesold, Katrin$$uInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 700__ $$aKrauter, Steffi$$uInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 700__ $$aPlachter, Bodo$$uInstitute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 700__ $$aHanik, Nils$$uDepartment of Chemistry, University of Fribourg, Switzerland 000029029 700__ $$aKilbinger, Andreas F. M.$$uDepartment of Chemistry, University of Fribourg, Switzerland 000029029 700__ $$aLambert, Carsten$$uDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 700__ $$aFlorin, Luise$$uDepartment of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany 000029029 773__ $$g2012/56/15/75-82$$tAntimicrobial Agents and Chemotherapy 000029029 775__ $$gPublished version$$ohttp://dx.doi.org/10.1128/AAC.05147-11 000029029 8564_ $$fkil_psi.pdf$$qapplication/pdf$$s296220$$uhttps://doc.rero.ch/record/29029/files/kil_psi.pdf$$yorder:1$$zpdf 000029029 8564_ $$fkil_psi_sm.pdf$$qapplication/pdf$$s99316$$uhttps://doc.rero.ch/record/29029/files/kil_psi_sm.pdf$$yorder:2$$zSupplementary material 000029029 918__ $$aFaculté des sciences$$bDécanat, Ch. du Musée 6A, 1700 Fribourg$$cChimie 000029029 919__ $$aUniversité de Fribourg$$bFribourg$$ddoc.support@rero.ch 000029029 980__ $$aPOSTPRINT$$bUNIFR$$fART_JOURNAL 000029029 990__ $$a20120427081609-JA