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Multifocal Vasculopathy Due to Varicella-Zoster Virus (VZV): Serial Analysis of VZV DNA and Intrathecal Synthesis of VZV Antibody in Cerebrospinal Fluid

Kronenberg, Andreas ; Schupbach, Reto ; Schuknecht, Bernhard ; Bossart, Walter ; Weber, Rainer ; Gilden, Donald H. ; Speck, Roberto F.

In: Clinical Infectious Diseases, 2002, vol. 35, no. 3, p. 330-333

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    Title
    • Multifocal Vasculopathy Due to Varicella-Zoster Virus (VZV): Serial Analysis of VZV DNA and Intrathecal Synthesis of VZV Antibody in Cerebrospinal Fluid
    Author
    • Kronenberg, Andreas. Division of Infectious Diseases and Hospital Epidemiology, Switzerland
    • Schupbach, Reto. Department of Internal Medicine, Switzerland
    • Schuknecht, Bernhard. Department of Institute of Neuroradiology, Switzerland
    • Bossart, Walter. Department of Institute of Medical Virology, University Hospital Zurich, Switzerland
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, Switzerland
    • Gilden, Donald H.. Departments of Neurology and Microbiology, University of Colorado Health Sciences Center, Denver
    • Speck, Roberto F.. Division of Infectious Diseases and Hospital Epidemiology, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2002, vol. 35, no. 3, p. 330-333. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:290284
    Summary
    Recognition of multifocal vasculopathy due to varicella-zoster virus (VZV) is often problematic. We describe a human immunodeficiency virus—infected patient who had progressive central nervous system disease for >3 months. Both VZV DNA and antibody were detected in cerebrospinal fluid (CSF) specimens; serial polymerase chain reaction analyses confirmed the diagnosis and guided the duration of therapy. Reduced ratios of VZV antibody in serum to that in CSF were also demonstrated