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Prophylaxis Failure Is Associated with a Specific Pneumocystis carinii Genotype

Hauser, Philippe M. ; Sudre, Philippe ; Nahimana, Aimable ; Francioli, Patrick

In: Clinical Infectious Diseases, 2001, vol. 33, no. 7, p. 1080-1082

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    Title
    • Prophylaxis Failure Is Associated with a Specific Pneumocystis carinii Genotype
    Author
    • Hauser, Philippe M.. Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Sudre, Philippe. Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Nahimana, Aimable. Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Francioli, Patrick. Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2001, vol. 33, no. 7, p. 1080-1082. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:290262
    Summary
    To investigate the possible association between Pneumocystis carinii types and various clinical and demographic parameters, we used molecular typing to analyze 93 bronchoalveolar lavage specimens from patients with P. carinii pneumonia (PCP). Multivariate regression analysis revealed an association between being infected with a specific P. carinii genotype and receiving anti-PCP prophylaxis (odds ratio, 4.4; 95% confidence interval, 1.0-18.6; P = .05), although no association with a specific drug was detected